AI Article Synopsis
- The lung clearance index (LCI) in adults with cystic fibrosis (CF) indicates differences in how air moves through the lungs, relating to both acinar and conductive ventilation.
- Researchers found a connection between LCI and how many bronchial segments are affected by bronchiectasis, confirming this in CF patients and another group with non-CF bronchiectasis.
- They concluded that the severity of lung disease, measured by the number of impacted bronchial segments, leads to a rise in LCI that may not improve with treatment in CF patients.
Article Abstract
In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.
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| http://dx.doi.org/10.1136/thoraxjnl-2017-210496 | DOI Listing |
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