Parkinson's disease is a chronic illness that affects motor skills. The Unified Parkinson's Disease Rating Scale sponsored by the Movement Disorder Society (MDS-UPDRS) quantifies the current state of the disease based on clinician's observations. In this scale, turning is part of the gait assessment, yet specific guidelines on which features to observe and rate are still unclear. What is more, only visual impairment detection is used as the main subjective rating tool. In this respect, four biomechanical features are extracted from sensors worn on the lower limbs in this work. Afterwards, a turning assessment score is computed by means of a fuzzy inference model constructed based on the examiners knowledge. Overall, 46 patients with varying motor impairment severity underwent a full MDS-UPDRS motor examination and were monitored using a measurement system that includes inertial sensors on each ankle. Turning rating scores computed are reasonably consistent with examiners opinions. Nevertheless, the model proposed herein will always output the same score given the same inputs; whereas the subjective nature of examiners observations translates into uncertainty and variability in the rating scores. Furthermore, the continuous scale implemented in this work prevents the floor/ceiling effect inherent of discrete scales.
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http://dx.doi.org/10.1016/j.compbiomed.2017.08.026 | DOI Listing |
Zool Res
January 2025
Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong 266071, China. E-mail:
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease (PD), supporting the "body-first" hypothesis. However, there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research.
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January 2025
Service de neurologie, Clinique bernoise Montana, 3963 Crans-Montana.
Parkinson's disease affects around 6 million people worldwide. It causes both motor and non-motor symptoms. Since there is no cure, medical treatment aims to improve patients' quality of life.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), KU Leuven, Leuven, Belgium.
Introduction: Freezing of gait (FOG) is a disabling symptom for people with Parkinson's disease (PwPD). Turning on the spot for one minute in alternating directions (360 turn) while performing a cognitive dual-task (DT) is a fast and sensitive way to provoke FOG. The FOG-index is a widely used wearable sensor-based algorithm to quantify FOG severity during turning.
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January 2025
Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, Munich 81377, Germany.
Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e.
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January 2025
Department of Clinical Medicine, Aarhus University Hospital, Aarhus N, 8200 Aarhus, Denmark.
Asymmetric dopaminergic degeneration of the striatum is a characteristic feature of Parkinson's disease, associated with right-left asymmetry in motor function. As such, studying asymmetry provides insights into progressive neurodegeneration between cerebral hemispheres. Given the impact of Lewy pathology on various neurotransmitter systems beyond the dopaminergic, it may be that other neuronal systems in the predominantly affected hemisphere are similarly affected.
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