Background: In our first report on antibody levels in middle-aged and older men with recurrent laryngeal papillomatosis (RLP), we reported increases in human papillomavirus (HPV) antibody levels similar to those seen in adult women and young men. We posited that HPV antibodies produced in laryngeal mucus by Gardasil would prevent postoperative reinfection in patients with RLP.
Study Design: This is a case series study.
Purpose: The purpose of this study was to examine whether Gardasil injection effectively inhibits recurrence of RLP. Specifically, in this second report, whether HPV antibodies produced in laryngeal secretions by Gardasil are capable of causing negative conversion of HPV-DNA (deoxyribonucleic acid) in laryngeal mucosa was investigated.
Methods: A total of 11 patients for whom antibodies were measured in the first report were studied. Before vaccination and after 1 year Post-vaccination, HPV screening tests were performed on laryngeal secretions, and whether HPV-DNA negative conversion had occurred was evaluated. At the time of collection of laryngeal secretions, the presence or absence of laryngeal papillomas was examined.
Results: Before vaccination, all patients were HPV low-risk positive on laryngeal secretion screening tests. After vaccination, three patients were positive. Laryngeal papillomas remained in five patients.
Conclusions: The HPV-DNA test showed negative conversion in eight of 11 (72.7%) patients after vaccination. Residual laryngeal papillomas were found in five of 11 (45.5%) patients. The serum HPV antibody titer did not differ significantly between the group in which laryngeal secretions showed HPV negative conversion and the group in which conversion did not occur. The serum antibody titer did not differ significantly as a function of whether there were residual tumors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jvoice.2017.07.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018-2023.
Front Public Health
January 2025
Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, China.
Objective: This study aimed to uncover the patterns of Human papillomavirus (HPV) infection outcomes in women and assess the risk factors that may affect these outcomes.
Methods: A retrospective study was conducted on 608 women who tested positive for HPV-DNA during their initial visit to the outpatient department of Shenzhen Longgang Central Hospital from 2018 to 2023 and who had subsequent HPV-DNA testing as part of their post-visit monitoring. The monitoring intervals were every 6 months.
In situ generation of Copper sulfide within Poly(lactic-co-glycolic acid): A strategy for Safer photothermal therapy in Triple-Negative breast cancer.
Int J Pharm
January 2025
Department of Pharmacy, 900TH Hospital of Joint Logistics Support Force, Fuzhou 350025, China. Electronic address:
Copper sulfide nanoparticles (CuS NPs) have garnered significant attention in photothermal therapy (PTT) owing to their facile synthesis, biodegradability, stability, and excellent photothermal conversion efficiency. Nonetheless, their potential toxic effects have restricted their application. This research focuses on the encapsulation of CuS NPs with the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA) to enhance their biocompatibility, thereby improving the efficacy and safety of PTT in the treatment of triple-negative breast cancer (TNBC).
View Article and Find Full Text PDFFoaming ink for 3D-printing of ultralight and hyperelastic graphene architectures: Multiscale design and ultra-efficient electromagnetic interference shielding.
J Colloid Interface Sci
January 2025
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 China; Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, School of Advanced Manufacturing, Guangdong University of Technology, Jieyang 515200 China. Electronic address:
Extrusion-based printing of macroscopic architectures layer-by-layer offers new opportunities for constructing customized electromagnetic interference (EMI) shielding materials. However, current research primarily focuses on improving the printability of material inks by increasing contents and adding various modifiers, controllable construction of ultralight and robust macro-architectures with structural design at both macro- and micro-scales is still challenging. Herein, we develop a graphene oxide foaming ink enriched with air bubbles for direct-ink writing, enabling the creation of macroscopic graphene architectures with arbitrary geometries.
View Article and Find Full Text PDFClinical Characteristics During and After COVID-19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China.
Immun Inflamm Dis
January 2025
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Revealing the clinical manifestations and associations of COVID-19 before and after negative transition remains an area of significant uncertainty. The aim of this study is to investigate the clinical characteristics observed during and after Omicron infection among a specific population, namely healthcare workers (HCWs).
Methods: From November 4, 2022, to January 15, 2023, HCWs in our hospital were enrolled to document clinical symptoms, prevention, and treatment for COVID-19 using a structured questionnaire.
Performance of 1-year-old camel calves fed a basal ration of alfalfa hay supplemented with different levels of concentrate.
BMC Vet Res
January 2025
Animal Production Department, National Research Centre, Cairo, Egypt.
Background: The use of a high-concentrate diet in fattening camels may have significant effects on growth performance and digestion as well as economic returns. This experiment was designed to study the effects of feeding different levels of concentrate in their diet on growth performance and digestion in a desert climate.
Methods: Eighteen 12-month-old male camel calves were used, and divided into three treatments of six each.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!