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Photo-controlled aptamers delivery by dual surface gold-magnetic nanoparticles for targeted cancer therapy. | LitMetric
Dual surfaced dumbbell-like gold magnetic nanoparticles (Au-FeO) were synthesized for targeted aptamers delivery. Their unique biological properties were characterized as a smart photo-controlled drug carrier. DNA aptamers targeting vascular endothelial growth factor (VEGF) were assembled onto the surface of Au-FeO by electrostatic absorption. The binding capacity of the nanoparticles with VEGF aptamers was confirmed by gel electrophoresis. The targeted recognization of ovarian cancer cells by the aptamers-functionalized Au-FeO nanoparticles (Apt-Au-FeO NPs) was observed by confocal microscopy. Apt-Au-FeO was found to bind with SKOV-3 ovarian cancer cells specifically, leading to marked intracellular release of aptamers upon plasmon-resonant light (605nm) radiation, and to enhance the in vitro inhibition against tumor cell proliferation. The results show high potential of Apt-Au-FeOas a targeted cancer hyperthermia carrier by remote control with high spatial/temporal resolution.
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