AI Article Synopsis
- The future of science is leaning towards interdisciplinary fields like biomedical engineering.
- Self-assembled structures can mimic stem cell niches, helping capture stem cells and slow down rapid cell division.
- By adjusting surface texture and stiffness, researchers successfully differentiated progenitor cells into endothelial cell layers that reduce blood coagulation.
Article Abstract
The future and development of science are in interdisciplinary areas, such as biomedical engineering. Self-assembled structures, similar to stem cell niches, inhibit rapid cellular division processes and enable the capture of stem cells from blood flow. By modifying the surface topography and stiffness properties, progenitor cells were differentiated towards the formation of endothelial cell monolayers to effectively inhibit the coagulation cascade. Wrinkled material layers in the form of thin polymeric coatings were prepared. An optimized surface topography led to proper cell differentiation and influenced the appropriate formation of endothelial cell monolayers. Blood activation was decelerated by the formed endothelium.
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| http://dx.doi.org/10.1016/j.msec.2017.06.005 | DOI Listing |
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