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Microstructure-based nuclear lamina constitutive model.
Cytoskeleton (Hoboken)
August 2024
Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois, USA.
The nuclear lamina is widely recognized as the most crucial component in providing mechanical stability to the nucleus. However, it is still a significant challenge to model the mechanics of this multilayered protein network. We developed a constitutive model of the nuclear lamina network based on its microstructure, which accounts for the deformation phases at the dimer level, as well as the orientational arrangement and density of lamin filaments.
View Article and Find Full Text PDFBio-Inspired Magnetically Controlled Reversibly Actuating Multimaterial Fibers.
Polymers (Basel)
May 2023
Institute of Active Polymers, Helmholtz-Zentrum Hereon, Kantstr. 55, 14513 Teltow, Germany.
Movements in plants, such as the coiling of tendrils in climbing plants, have been studied as inspiration for coiling actuators in robotics. A promising approach to mimic this behavior is the use of multimaterial systems that show different elastic moduli. Here, we report on the development of magnetically controllable/triggerable multimaterial fibers (MMFs) as artificial tendrils, which can reversibly coil and uncoil on stimulation from an alternating magnetic field.
View Article and Find Full Text PDFMetastasis enhancer PGRMC1 boosts store-operated Ca entry by uncoiling Ca sensor STIM1 for focal adhesion turnover and actomyosin formation.
Cell Rep
January 2022
Department of Biological Sciences, Ulsan National Institute of Science and Technology, 44919, Ulsan, Republic of Korea. Electronic address:
Progesterone receptor membrane component 1 (PGRMC1), the overexpression of which reduces survivability of cancer patients, is essential for cell migration and metastasis. However, the intracellular signaling pathways involved are largely unknown. Here, we report that PGRMC1 promotes store-operated Ca entry (SOCE) as a functional interactor of stromal interaction molecule 1 (STIM1).
View Article and Find Full Text PDFCoiled-Coil Domain: Uncoiling Tumor Suppression by BRCA1.
Cancer Res
December 2021
Mouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland.
The coiled-coil domain of BRCA1 is essential for its interaction with partner and localizer of BRCA2 (PALB2). In mice, loss of this interaction is known to result in Fanconi anemia-associated phenotypes. In a study published in this issue of , Pulver and colleagues from the Jonkers lab have generated a mouse model with a leucine to proline change in codon 1363 in the coiled-coil domain of BRCA1 ( ), which disrupts its binding with PALB2.
View Article and Find Full Text PDFThe myosin II coiled-coil domain atomic structure in its native environment.
Proc Natl Acad Sci U S A
April 2021
Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306-4380;
The atomic structure of the complete myosin tail within thick filaments isolated from flight muscle is described and compared to crystal structures of recombinant, human cardiac myosin tail segments. Overall, the agreement is good with three exceptions: the proximal S2, in which the filament has heads attached but the crystal structure doesn't, and skip regions 2 and 4. At the head-tail junction, the tail α-helices are asymmetrically structured encompassing well-defined unfolding of 12 residues for one myosin tail, ∼4 residues of the other, and different degrees of α-helix unwinding for both tail α-helices, thereby providing an atomic resolution description of coiled-coil "uncoiling" at the head-tail junction.
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