AI Article Synopsis
- Host-directed therapies that enhance the immune response could be key in improving tuberculosis (TB) treatment outcomes.
- A study using denileukin diftitox in mice showed that it enhances the effectiveness of standard TB treatments by reducing certain suppressor cell types in the body.
- These findings suggest that denileukin diftitox and similar therapies might be promising options for adjunctive treatment strategies against TB.
Article Abstract
Host-directed therapies that augment host immune effector mechanisms may serve as important adjunctive therapies for tuberculosis treatment. We evaluated the activity of denileukin diftitox in an acute mouse model of tuberculosis (TB) infection and analyzed the cellular composition and bacterial burden in lungs and spleens. These in vivo studies show that denileukin diftitox potentiates standard TB treatment in the mouse model, an effect which may be due to depletion of T-regulatory and myeloid-derived suppressor cells during TB infection. Our results indicate that denileukin diftitox and other suppressor cell-depleting therapies may be useful adjunctive, host-directed therapies for TB.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853937 | PMC |
| http://dx.doi.org/10.1093/infdis/jix208 | DOI Listing |
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