A transgender patient presenting as a female sought dental care with her primary concern being a desire to change the appearance of her teeth. Open initial communication regarding the patient's gender status helped enable the clinician to gain a more thorough understanding of how medications taken by the patient could affect dental treatment. In this case, estradiol taken in constant doses impeded necessary orthodontic movement of the teeth, and the dosing, therefore, was modified to enhance treatment. The case report describes a full-mouth reconstruction for the transgender patient.
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