Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddition of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective, producing stable aziridinyl iminosugars in high yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.7b02283 | DOI Listing |
Publication Analysis
Top Keywords
cyclic nitrones
8
aziridinyl iminosugars
8
aziridination cyclic
4
nitrones targeting
4
targeting constrained
4
constrained iminosugars
4
iminosugars rare
4
rare c-7-substituted
4
c-7-substituted aziridinyl
4
iminosugars synthesized
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!