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Identification of core genes related to exosomes and screening of potential targets in periodontitis using transcriptome profiling at the single-cell level.
BMC Oral Health
January 2025
Department of Stomatology, People's Hospital of Xinjiang Autonomous Region, Urumqi City, China.
Background: The progression and severity of periodontitis (PD) are associated with the release of extracellular vesicles by periodontal tissue cells. However, the precise mechanisms through which exosome-related genes (ERGs) influence PD remain unclear. This study aimed to investigate the role and potential mechanisms of key exosome-related genes in PD using transcriptome profiling at the single-cell level.
View Article and Find Full Text PDFCuttlefish favour their current need to hide rather than their future need for food.
Learn Behav
January 2025
Normandie UnivUnicaen, CNRS, EthoS, 14000, Caen, France.
Episodic memory and future thinking are generally considered as two parts of the same mental time travelling system in vertebrates. Modern cephalopods, with their independent evolutionary lineage and their complex cognitive abilities, appear as promising species to determine whether these abilities have separate evolutionary histories or not. In our study, we tested future-planning abilities in a cephalopod species which has been shown to possess episodic-like memory abilities: the common cuttlefish.
View Article and Find Full Text PDFNovel inhibition of sortase A by plantamajoside: implications for controlling multidrug-resistant infections.
Appl Environ Microbiol
December 2024
Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Article Synopsis
- The research introduces plantamajoside (PMS) as an innovative inhibitor of sortase A (SrtA), an enzyme crucial for the virulence of methicillin-resistant Staphylococcus aureus (MRSA), showcasing its potential in combating multi-drug resistant pathogens.
- PMS effectively reduces MRSA's ability to adhere to surfaces and form biofilms, leading to increased survival rates in infected cell models and proving beneficial in animal models by lowering mortality rates and bacterial loads.
- The findings emphasize the significance of targeting specific bacterial mechanisms, such as SrtA, to develop new therapeutic strategies against antibiotic-resistant infections, particularly MRSA.
HPV-Associated Gene Signatures in Bladder Cancer: A Comprehensive Prognostic Model and its Implications in Immunotherapy.
Int J Med Sci
January 2025
Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
Evidence increasingly indicates that HPV infection plays a pivotal role in the initiation and progression of bladder cancer (BC). Yet, determining the predictive value of HPV-associated genes in BC remains challenging. We identified differentially expressed HPV-associated genes of BC patients from the TCGA and GEO databases.
View Article and Find Full Text PDFCataloging metagenome-assembled genomes and microbial genes from the athlete gut microbiome.
Microbiome Res Rep
July 2024
Teagasc Food Research Centre, Moorepark, Fermoy, Cork P61 C996, Ireland.
Article Synopsis
- Exercise has been identified as a factor influencing the gut microbiome, but previous findings have been inconsistent, particularly concerning specific sports.
- The study utilizes publicly available data from athlete gut microbiome research to analyze how exercise affects gut bacteria, discovering 76 species linked to exercise and identifying potential novel species through metagenomic assembly of approximately 2,000 genomes.
- The results indicate significant patterns in the microbiome associated with different sports and suggest that using metagenomics can enhance our understanding of the relationship between exercise and gut health, potentially leading to probiotic development.
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