DNA damage-induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. http://dx.doi.org/10.1038/nature23449), and Bartsch et al. (2017. https://doi.org/10.1093/hmg/ddx283) demonstrate a role for micronuclei formation in DNA damage-induced immune activation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626557 | PMC |
| http://dx.doi.org/10.1083/jcb.201708069 | DOI Listing |
Publication Analysis
Top Keywords
dna damage-induced
12
damage-induced immune
8
dna
4
immune response
4
response micronuclei
4
micronuclei provide
4
provide key
4
key platform
4
platform dna
4
damage-induced activation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!