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Radiofrequency Microneedling in Treating Primary Hyperhidrosis: A Systematic Review and Meta-Analysis.
Dermatol Surg
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Background: Radiofrequency microneedling (RFM) is a potential treatment for primary hyperhidrosis. However, its efficacy is unclear, and treatment parameters and outcomes vary across studies.
Objective: To understand the effect of RFM on treating primary hyperhidrosis, as measured by changes in the Hyperhidrosis Disease Severity Score (HDSS) before and after treatment, and to clearly define treatment settings most likely to optimize results.
Multi-Layered Microneedles Loaded with Microspheres.
AAPS PharmSciTech
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A..
Delivery of therapies into skin is attractive for medical indications including vaccination and treatment of dermatoses but is highly constrained by the stratum corneum barrier. Microneedle (MN) patches have emerged as a promising technology to enable non-invasive, intuitive, and low-cost skin delivery. When combined with biodegradable polymer formulations, MN patches can further enable controlled-release drug delivery without injection.
View Article and Find Full Text PDFSelf-Delivering RNAi Compounds for Reduction of Hyperpigmentation.
Clin Cosmet Investig Dermatol
December 2024
Phio Pharmaceuticals, Marlborough, MA, USA.
Purpose: Abnormal melanin synthesis causes hyperpigmentation disorders like melasma and lentigines, impacting psychological well-being. RNA interference (RNAi) uses small RNA molecules to inhibit gene expression by targeting specific mRNA, silencing genes involved in undesirable cellular functions. This study assessed INTASYL compounds, self-delivering RNAi molecules, designed to target and reduce tyrosinase gene expression to decrease pigmentation.
View Article and Find Full Text PDFAdvances in Drug Delivery Systems for Atopic Dermatitis Treatment.
Chembiochem
December 2024
University of Shanghai for Science and Technology, School of Materials and Chemistry, CHINA.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and impaired skin barrier function. Advances in drug delivery systems have transformed AD treatment by enhancing drug stability, bioavailability, and targeted delivery. Drug delivery systems such as liposomes, hydrogels, and microneedles enable deeper skin penetration, prolonged drug retention, and controlled release, reducing side effects and treatment frequency.
View Article and Find Full Text PDFReview of Applications of Microneedling in Melasma.
J Cosmet Dermatol
January 2025
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
Background: Melasma, a common skin pigmentation disease, can negatively impact patients' mental health, social interactions, and physical appearance. Although we now have several treatments accessible, such as medicines, chemical peels, and phototherapy, which can help ease symptoms to some extent, the requirement for a long-term effective and safe treatment for patients is far from met. In the face of this problem, microneedling, as an innovative treatment, provides a new avenue for treating melasma.
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