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Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats.
Pharmaceutics
January 2025
Department of Pharmacology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.
Background: This is a novel rat study using native peptide therapy, focused on reversing quadriceps muscle-to-bone detachment to reattachment and stable gastric pentadecapeptide BPC 157 per-oral therapy for shared muscle healing and function restoration.
Methods: Pharmacotherapy recovering various muscle, tendon, ligament, and bone lesions, and severed junctions (i.e.
Bone Composition Changes and Calcium Metabolism in Obese Adolescents and Young Adults Undergoing Sleeve Gastrectomy: A Systematic Review.
J Clin Med
January 2025
Surgical Oncology Department, Emergency County Hospital Oradea, Strada Gheorghe Doja 65, 410169 Oradea, Romania.
: Sleeve gastrectomy (SG) is increasingly used to treat severe obesity in adolescents, but its effects on bone health during this critical period of bone accrual are not fully understood. This systematic review aims to evaluate the impact of SG on the bone mineral density (BMD), bone microarchitecture, marrow adipose tissue (MAT), and bone turnover markers in adolescents. : A comprehensive literature search was conducted to identify studies assessing bone health outcomes in adolescents undergoing SG.
View Article and Find Full Text PDFSandwiched Strut Allografts with Stem Retention to Treat Fragile Periprosthetic Femoral Fractures: A Case Report.
Medicina (Kaunas)
January 2025
Department of Orthopaedic Surgery, Chosun University Hospital, 365 Pilmundae-ro, Dong-gu, Gwangju 61453, Republic of Korea.
Managing periprosthetic femoral fractures is challenging, particularly in osteoporotic patients with fragile bones. Revision with a long stem is commonly considered but may fail to provide adequate fixation and stability in fragile bones. A novel approach using sandwiched strut allografts and controlled bone crushing with robust cable fixation can offer mechanical support and provide secondary stability to the loosened femoral stem and can be considered a treatment option for low-demand patients.
View Article and Find Full Text PDFMulti-Scale Characterisation and Mechanical Adhesion in PVD-Deposited Ca-SZ Coating for Implantable Medical Devices.
Biomedicines
December 2024
Jean Lamour Institute, Department of Micro and Nanomechanics for Life, University of Lorraine, UMR 7198, 54011 Nancy, France.
Oral implantology faces a multitude of technical challenges in light of current clinical experience, underlining the need for innovation in implantable medical devices in both mechanical and biological terms. This study explores the influence of the thickness factor of calcium-doped zirconia (Ca-SZ) coatings deposited by PVD on their intrinsic mechanical properties and the determinism of the latter on adhesion to the TA6V alloy substrate after mechanical loading for applications in dental implantology. Three separate thicknesses of 250 nm, 450 nm and 850 nm were evaluated in terms of mechanical strength, modulus of elasticity and adhesion to the substrate, in accordance with ISO 20502:2005.
View Article and Find Full Text PDFFAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption.
Biology (Basel)
January 2025
Southern California Institute for Research and Education, VA Long Beach Medical Center, Long Beach, CA 90822, USA.
There are three FAM98 family proteins (FAM98A/B/C) in humans and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 in murine osteoclasts and functions in lysosome trafficking/secretion and bone resorption in osteoclasts in vitro.
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