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Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma.
ERJ Open Res
November 2024
Department of Pulmonary Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Background: Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma.
Methods: Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6-17 years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries.
Upper Urinary Tract Stereotactic Body Radiotherapy Using a 1.5 Tesla Magnetic Resonance Imaging-Guided Linear Accelerator: Workflow and Physics Considerations.
Cancers (Basel)
November 2024
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Advancements in radiotherapy technology now enable the delivery of ablative doses to targets in the upper urinary tract, including primary renal cell carcinoma (RCC) or upper tract urothelial carcinomas (UTUC), and secondary involvement by other histologies. Magnetic resonance imaging-guided linear accelerators (MR-Linacs) have shown promise to further improve the precision and adaptability of stereotactic body radiotherapy (SBRT). This single-institution retrospective study analyzed 34 patients (31 with upper urinary tract non-metastatic primaries [RCC or UTUC] and 3 with metastases of non-genitourinary histology) who received SBRT from August 2020 through September 2024 using a 1.
View Article and Find Full Text PDFExploring the potential mechanisms of Maxim in preventing alcoholic liver disease based on network pharmacology and molecular docking.
Nat Prod Res
December 2024
College of Agricultural, Yanbian University, Yanji, Jilin, China.
Article Synopsis
- * The five main active components found in AT were kaempferol-3-rhamnoside, salidroside, linoleic acid, ethyl linoleate, and tyrosol, while the key target proteins involved in preventing ALD were SRC, AKT1, STAT3, MAPK1, and ESR1.
- * Gene enrichment analysis suggested that AT may work by targeting inflammation and cancer pathways, highlighting the complex interactions between its components, targets, and pathways in preventing ALD.
Implanted cortical neuroprosthetics for speech and movement restoration.
J Neurol
November 2024
The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
Implanted cortical neuroprosthetics (ICNs) are medical devices developed to replace dysfunctional neural pathways by creating information exchange between the brain and a digital system which can facilitate interaction with the external world. Over the last decade, researchers have explored the application of ICNs for diverse conditions including blindness, aphasia, and paralysis. Both transcranial and endovascular approaches have been used to record neural activity in humans, and in a laboratory setting, high-performance decoding of the signals associated with speech intention has been demonstrated.
View Article and Find Full Text PDFPeripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models.
JCI Insight
September 2024
Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience.
Chronic pain is a complex, debilitating, and escalating health problem worldwide, impacting 1 in 5 adults. Current treatment is compromised by dose-limiting side effects, including high abuse liability, loss of ability to function socially and professionally, fatigue, drowsiness, and apathy. PICK1 has emerged as a promising target for the treatment of chronic pain conditions.
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