Host-microbiota interactions and adaptive immunity.

Immunol Rev

Department of Microbiology, Immunology and Infectious Diseases, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Published: September 2017

All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen-specificity of the T-cell compartment.

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12575DOI Listing

Publication Analysis

Top Keywords

adaptive immunity
8
immune system
8
host-microbiota interactions
4
interactions adaptive
4
immunity mucosal
4
mucosal surfaces
4
surfaces colonized
4
colonized vast
4
vast number
4
number microbes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!