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Mapping of the Glucose Metabolism Heterogeneity in Atherosclerosis: Correlation With 2-Deoxyglucose Uptake.
Mol Imaging
November 2024
Departments of Radiology, Division of Cardiothoracic Imaging, University of Pittsburgh, Pittsburgh, PA, USA.
Objective: 2-Deoxy-2-[F]fluoro-D-glucose ([F]FDG) is widely used for noninvasive imaging of atherosclerosis. However, knowledge about metabolic processes underlying [F]FDG uptake is mostly derived from cell culture studies, which cannot recapitulate the complexities of the plaque microenvironment. Here, we sought to address this gap by mapping of the activity of selected major dehydrogenases involved in glucose metabolism in atherosclerotic plaques.
View Article and Find Full Text PDFActivities of Energy and Carbohydrate Metabolism Enzymes in Rainbow Trout Оncorhynchus mykiss Walb. upon Introduction of 24-hour Lighting in Aquaculture in Southern Russia.
Dokl Biol Sci
December 2024
Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia.
Activities of energy and carbohydrate metabolism enzymes (cytochrome c oxidase (COX), pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (G6PD), glycerol 1-phosphate dehydrogenase (G1PDH), lactate dehydrogenase (LDH), and aldolase) were studied in rainbow trout Oncorhynchus mykiss Walb. fish grown in aquaculture in North Ossetia-Alania after introducing a regime with 24-h lighting and night feeding. COX and PK activities in the liver of fish from the experimental group were found to be significantly higher than in control fish, indicating an increase in aerobic ATP synthesis.
View Article and Find Full Text PDFIncreased exercise tolerance in humanized G6PD-deficient mice.
Blood Adv
January 2025
Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Article Synopsis
- - Glucose-6-phosphate dehydrogenase (G6PD) deficiency, affecting 500 million people, impairs red blood cell antioxidant functions, raising the risk of hemolysis during oxidative stress, particularly during exercise.
- - A study using mice with a specific G6PD variant showed that, despite lower enzyme activity, these mice had better exercise performance and improved heart function post-exercise compared to normal mice.
- - Analysis revealed enhanced mitochondrial function and changes in energy metabolism and protein turnover, indicating that G6PD-deficient individuals might have a metabolic advantage during exercise, challenging existing beliefs about hemolytic risks.
Engineered Cardiac Tissues as a Platform for CRISPR-Based Mitogen Discovery.
Adv Healthc Mater
January 2025
Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Improved understanding of cardiomyocyte (CM) cell cycle regulation may allow researchers to stimulate pro-regenerative effects in injured hearts or promote maturation of human stem cell-derived CMs. Gene therapies, in particular, hold promise to induce controlled proliferation of endogenous or transplanted CMs via transient activation of mitogenic processes. Methods to identify and characterize candidate cardiac mitogens in vitro can accelerate translational efforts and contribute to the understanding of the complex regulatory landscape of CM proliferation and postnatal maturation.
View Article and Find Full Text PDFGlucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer's disease.
Redox Biol
September 2024
Freshage Research Group, Department of Physiology. Faculty of Medicine, University of Valencia, CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
Mice models of Alzheimer's disease (APP/PS1) typically experience cognitive decline with age. G6PD overexpressing mice (G6PD-Tg) exhibit better protection from age-associated functional decline including improvements in metabolic and muscle functions as well as reduced frailty compared to their wild-type counterparts. Importantly G6PD-Tg mice show diminished accumulation of DNA oxidation in the brain at different ages in both males and females.
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