Introduction: Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD.
Methods: We investigated 18 patients with early AD and 18 healthy control subjects using C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging. The PET images were normalized and underwent voxelwise regression analysis with each subregion volumes using SPM12.
Results: As for F-THK5351 PET, the bilateral perirhinal cortex volumes were significantly associated with the ipsilateral or bilateral temporal lobar uptakes, whereas hippocampal subfields showed no correlations. C-PIB PET showed relatively broad negative correlation with the right cornu ammonis 3 volumes.
Discussion: Regional tau deposition was correlated with extrahippocampal subregional atrophy and not with hippocampal subfields, possibly reflecting different underlying mechanisms of atrophy in early AD. Amyloid might be associated with right cornu ammonis 3 atrophy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562105 | PMC |
| http://dx.doi.org/10.1016/j.dadm.2017.07.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pattern Separation and Pattern Completion Within the Hippocampal Circuit During Naturalistic Stimuli.
Hum Brain Mapp
February 2025
Research Center for Social Computing and Information Retrieval, Harbin Institute of Technology, Harbin, China.
Pattern separation and pattern completion in the hippocampus play a critical role in episodic learning and memory. However, there is limited empirical evidence supporting the role of the hippocampal circuit in these processes during complex continuous experiences. In this study, we analyzed high-resolution fMRI data from the "Forrest Gump" open-access dataset (16 participants) using a sliding-window temporal autocorrelation approach to investigate whether the canonical hippocampal circuit (DG-CA3-CA1-SUB) shows evidence consistent with the occurrence of pattern separation or pattern completion during a naturalistic audio movie task.
View Article and Find Full Text PDFAltered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms.
BMC Rheumatol
January 2025
Department of Clinical Sciences, Diagnostic Radiology, Lund, Lund University, Lund, Sweden.
Background: Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal lobe (MTL) regions. Our study aims to compare MTL subregional volumes in SLE patients to healthy individuals (HI) and explore MTL subregional volumes in relation to neuropsychiatric SLE (NPSLE) manifestations.
View Article and Find Full Text PDFWalking and Hippocampal Formation Volume Changes: A Systematic Review.
Brain Sci
January 2025
Department of Architecture, University of Cambridge, Cambridge CB2 1PX, UK.
Background/objectives: Sustaining the human brain's hippocampus from atrophy throughout ageing is critical. Exercise is proven to be effective in promoting adaptive hippocampal plasticity, and the hippocampus has a bidirectional relationship with the physical environment. Therefore, this systematic review explores the effects of walking, a simple physical activity in the environment, on hippocampal formation volume changes for lifelong brain and cognitive health.
View Article and Find Full Text PDFPrenatal exposure to polycyclic aromatic hydrocarbons, reduced hippocampal subfield volumes, and word reading.
Dev Cogn Neurosci
January 2025
Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, United States; The Child Mind Institute, New York, NY, United States. Electronic address:
Reading difficulties and exposure to air pollution are both disproportionately high among youth living in economically disadvantaged contexts. Critically, variance in reading skills in youth living in higher socioeconomic status (SES) contexts largely derives from genetic factors, whereas environmental factors explain more of the variance in reading skills among youth living in lower SES contexts. Although reading research has focused closely on the psychosocial environment, little focus has been paid to the effects of the chemical environment.
View Article and Find Full Text PDFHippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study.
PLoS One
January 2025
National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Australia.
Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients share similar symptoms including post-exertional malaise, neurocognitive impairment, and memory loss. The neurocognitive impairment in both conditions might be linked to alterations in the hippocampal subfields. Therefore, this study compared alterations in hippocampal subfields of 17 long COVID, 29 ME/CFS patients, and 15 healthy controls (HC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!