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| http://dx.doi.org/10.3389/fpsyt.2017.00142 | DOI Listing |
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Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity and plasticity, challenging the traditional view of neutrophils as a homogeneous population with a limited functional repertoire. Advances in single-cell technologies and functional assays have revealed distinct neutrophil subsets with diverse phenotypes and functions and their ability to adapt to microenvironmental cues.
View Article and Find Full Text PDFFrailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort.
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Internal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
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Recent advances in the anti-tumor activities of saponins through cholesterol regulation.
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Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. Cholesterol regulation by saponins is a complex process that involves multiple mechanisms.
View Article and Find Full Text PDFPossible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from COVID-19.
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