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| http://dx.doi.org/10.3238/arztebl.2017.0559b | DOI Listing |
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Vascular and inflammatory biomarkers of cardiovascular events in non-steroidal anti-inflammatory drug users.
Eur Heart J Open
November 2024
The National Heart and Lung Institute, Imperial College London SW7 2AZ, UK.
Aims: The Standard care vs. Celecoxib Outcome Trial (SCOT) found similar risk of cardiovascular events with traditional non-steroidal anti-inflammatory drugs (NSAIDs) and the cyclooxygenase-2-selective drug celecoxib. While pre-clinical work has suggested roles for vascular and renal dysfunction in NSAID cardiovascular toxicity, our understanding of these mechanisms remains incomplete.
View Article and Find Full Text PDFCOX-2 optimizes cardiac mitochondrial biogenesis and exerts a cardioprotective effect during sepsis.
Cytokine
October 2024
Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, PR China; Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, Hunan Province, PR China; National Medicine Functional Experimental Teaching Center, Central South University, Changsha, Hunan Province, PR China. Electronic address:
Background: Septic cardiomyopathy is a component of multiple organ dysfunction in sepsis. Mitochondrial dysfunction plays an important role in septic cardiomyopathy. Studies have shown that cyclooxygenase-2 (COX-2) had a protective effect on the heart, and prostaglandin E (PGE), the downstream product of COX-2, was increasingly recognized to have a protective effect on mitochondrial function.
View Article and Find Full Text PDFBackground: The use of marijuana, derived from the Cannabis plant, has a lengthy history dating back thousands of years. With the recent legalization of marijuana in many US states, concerns about its health effects have grown. Despite traditional beliefs in its cardioprotective properties, there is a rising incidence of marijuana-induced pericarditis.
View Article and Find Full Text PDFMelatonin protects against diclofenac induced oxidative stress mediated myocardial toxicity in rats: A mechanistic insight.
Food Chem Toxicol
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Department of Physiology, Vidyasagar College, 39, Sankar Ghosh Lane, Kolkata, 700006, India. Electronic address:
Diclofenac, a traditional non-steroidal anti-inflammatory drug, is commonly used for treating chronic pain and inflammation. Recently, a number of articles have highlighted the toxicities associated with diclofenac. The current study explores the molecular mechanism of diclofenac induced cardiac toxicity following oxidative stress.
View Article and Find Full Text PDFSC-560 and mofezolac isosteres as new potent COX-1 selective inhibitors with antiplatelet effect.
Arch Pharm (Weinheim)
May 2023
Laboratory of Plant Biotechnologies, Institute of Experimental Botany of the Czech Academy of Sciences, Prague, Czech Republic.
Selective cyclooxygenase (COX)-1 inhibitors can be employed as potential cardioprotective drugs. Moreover, COX-1 plays a key role in inflammatory processes and its activity is associated with some types of cancer. In this work, we designed and synthesized a set of compounds that structurally mimic the selective COX-1 inhibitors, SC-560 and mofezolac, the central cores of which were replaced either with triazole or benzene rings.
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