AI Article Synopsis
- The mammalian inner ear includes six sensory organs: cochlea, utricle, saccule, and three semicircular canals, with the cochlea housing the organ of Corti for sound detection.
- During development, the inner ear undergoes morphogenesis initiated by the thickening of ectoderm near the hindbrain, requiring precise regulation of multiple signaling pathways like FGF, Wnt, Notch, and Bmp.
- This review focuses on the new insights into FGF signaling and its critical role in cochlear development.
Article Abstract
Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development. [BMB Reports 2017; 50(10): 487-495].
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683817 | PMC |
| http://dx.doi.org/10.5483/bmbrep.2017.50.10.164 | DOI Listing |
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