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Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.
Arch Toxicol
January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
View Article and Find Full Text PDFIn Vivo Animal Spices and Experimental Technique to Evaluate Sustained Release Granules.
Biopharm Drug Dispos
January 2025
Bioavailability Research Project, Formulation Research Institute, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan.
Establishment of a suitable animal model to evaluate sustained release (SR) formulations is very important because it reduces the development time of SR formulations. Beagle dogs are often used to evaluate prototype formulations since they can be directly administered powder, such as drug substance. However, the physiological condition of dogs is very different to that of humans.
View Article and Find Full Text PDFSilicon-mediated modulation of maize growth, metabolic responses, and antioxidant mechanisms under saline conditions.
BMC Plant Biol
January 2025
Department of Crop Sciences, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Purpose: This study explored how exogenous silicon (Si) affects growth and salt resistance in maize.
Methods: The maize was cultivated in sand-filled pots, incorporating varied silicon and salt stress (NaCl) treatments. Silicon was applied at 0, 2, 4, 6, and 8 mM, and salt stress was induced using 0, 60 and120 mM concentrations.
Green Tea Catechins as Perpetrators of Drug Pharmacokinetic Interactions.
Clin Pharmacol Ther
January 2025
Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Green tea (Camellia sinensis) is a commonly consumed beverage or dietary supplement. As a natural product with a myriad of proposed health benefits, patients are likely to consume green tea while taking their medications unaware of its potential to interact with drugs and influence drug efficacy and safety. Catechins are the abundant polyphenolic compounds in green tea (e.
View Article and Find Full Text PDFNon-targeted LC-MS metabolomics reveals serum metabolites for high-altitude adaptation in Tibetan donkeys.
Sci Rep
January 2025
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong, China.
Tibetan donkeys inhabit the harsh environment of the Qinghai-Tibet Plateau. Research on serum metabolites related to their high-altitude adaptation is limited compared to other livestock. We used liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from healthy adult donkeys in Shigatse, Changdu, and Dezhou to evaluate the effects of high altitudes on serum metabolites.
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