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FRESH extrusion 3D printing of type-1 collagen hydrogels photocrosslinked using ruthenium.
PLoS One
January 2025
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.
The extrusion bioprinting of collagen material has many applications relevant to tissue engineering and regenerative medicine. Freeform Reversible Embedding of Suspended Hydrogels (FRESH) technology is capable of 3D printing collagen material with the specifications and details needed for precise tissue guidance, a crucial requirement for effective tissue repair. While FRESH has shown repeated success and reliability for extrusion printing, the mechanical properties of completed collagen prints can be improved further by post-print crosslinking methodologies.
View Article and Find Full Text PDFHighly Self-Adhesive and Biodegradable Silk Bioelectronics for All-In-One Imperceptible Long-Term Electrophysiological Biosignals Monitoring.
Adv Sci (Weinh)
January 2025
Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, 34956, Türkiye.
Skin-like bioelectronics offer a transformative technological frontier, catering to continuous and real-time yet highly imperceptible and socially discreet digital healthcare. The key technological breakthrough enabling these innovations stems from advancements in novel material synthesis, with unparalleled possibilities such as conformability, miniature footprint, and elasticity. However, existing solutions still lack desirable properties like self-adhesivity, breathability, biodegradability, transparency, and fail to offer a streamlined and scalable fabrication process.
View Article and Find Full Text PDFSkin-Integrated Electrogenetic Regulation of Vasculature for Accelerated Wound Healing.
Adv Sci (Weinh)
January 2025
ETH Zurich, Department of Biosystems Science and Engineering, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Neo-vascularization plays a key role in achieving long-term viability of engineered cells contained in medical implants used in precision medicine. Moreover, strategies to promote neo-vascularization around medical implants may also be useful to promote the healing of deep wounds. In this context, a biocompatible, electroconductive borophene-poly(ε-caprolactone) (PCL) 3D platform is developed, which is called VOLT, to support designer cells engineered with a direct-current (DC) voltage-controlled gene circuit that drives secretion of vascular endothelial growth factor A (VEGFA).
View Article and Find Full Text PDFFluoride-Induced Autophagy and Apoptosis in the Mouse Ovary: Genomic Insights into IL-17 Signaling and Gut Microbiota Dysbiosis.
J Agric Food Chem
January 2025
Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China.
Chronic fluoride (F) exposure is linked to gonadotoxicity in females, yet the underlying molecular mechanisms remain unclear. This study investigated fluoride-induced reprotoxicity using advanced genomic profiling. RNA-seq analysis identified significant activation of autophagy, apoptosis, and IL-17 signaling pathways in fluoride-exposed female mice.
View Article and Find Full Text PDFA Lifetime of Catalytic Micro-/Nanomotors.
Nanomaterials (Basel)
December 2024
School of Electronic and Information Engineering, University of Science and Technology Liaoning, Anshan 114051, China.
Microscopic and nanoscopic motors, often referred to as micro-/nanomotors, are autonomous devices capable of converting chemical energy from their surroundings into mechanical motion or forces necessary for propulsion. These devices draw inspiration from natural biomolecular motor proteins, and in recent years, synthetic micro-/nanomotors have attracted significant attention. Among these, catalytic micro-/nanomotors have emerged as a prominent area of research.
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