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Frontal lobe development in fetuses with growth restriction by using ultrasound: a case-control study.
BMC Pregnancy Childbirth
November 2022
Department of Ultrasonic Medicine, Fetal Medical Centre, The First Affiliated Hospital of Sun Yat-Sen University, Zhongshan 2nd Road 58#, Guangzhou, Guangdong, China.
Background: Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is a leading cause of perinatal mortality and neonatal morbidity. Three-dimensional ultrasonography of intracranial structure volume revealed significant differences between fetuses with FGR and appropriate for gestational age (AGA) fetuses. We aimed to compare the frontal lobe development between fetuses with FGR and appropriately grown fetuses and evaluate the impact of fetal circulatory redistribution (FCR) on frontal lobe development in fetuses with FGR.
View Article and Find Full Text PDFClinician-reported chorionicity and zygosity assignment using single-nucleotide polymorphism-based cell-free DNA: Lessons learned from 55,344 twin pregnancies.
Prenat Diagn
September 2022
Department of Obstetrics, Gynecology, and Reproductive Science, Mt. Sinai, New York, NY, USA.
Objective: Prenatal chorionicity assessment relies on ultrasound, which can be confounded by many factors. Noninvasive assessment of zygosity is possible using single nucleotide polymorphism (SNP)-based cell-free DNA testing. Our objective was to determine the relationship between provider-reported chorionicity and SNP-cfDNA assignment of twin zygosity.
View Article and Find Full Text PDFO157:H7 Cluster Associated With Deer Harvested at a Single Wildlife Hunting Area, Oregon, 2017.
Public Health Rep
August 2022
378804 Public Health Division, Oregon Health Authority, Portland, OR, USA.
The Oregon Health Authority routinely investigates clusters of reportable enteric diseases identified by whole-genome sequencing. While investigating 2 cases of O157:H7 in 2019, in which both patients were exposed to the same home-processed "jerky" and clinical isolates matched within 2 single nucleotide polymorphisms (SNPs), we discovered, by searching the National Library of Medicine's National Center for Biotechnology Information website, 3 other cases of O157:H7 from 3 Oregon counties-Tillamook, Umatilla, and Douglas-whose clinical isolates were within 9 SNPs of the 2 initial matched cases. We analyzed interview data for 3 case patients and followed up with additional hypothesis-generating questions.
View Article and Find Full Text PDFVisceral adiposity and inflammatory bowel disease.
Int J Colorectal Dis
November 2021
Department of Gastroenterology, Beaumont Hospital, Beaumont Rd, Dublin, Ireland.
Background: Rates of obesity are increasing worldwide, as is the incidence of inflammatory bowel disease (IBD). Obesity is now considered an inflammatory state. Visceral adiposity in particular may be associated with a more severe inflammatory phenotype in IBD.
View Article and Find Full Text PDFGenetic polymorphisms in pri-let-7a-2 are associated with ischemic stroke risk in a Chinese Han population from Liaoning, China: a case-control study.
Neural Regen Res
July 2021
Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
Article Synopsis
- Ischemic stroke is influenced by genetic variations, particularly involving the microRNA let-7a, which may play a role in its development.
- A study involving 1,086 stroke patients and 836 healthy controls found specific genetic variants (rs1143770 and rs629367) linked to decreased and increased risk of stroke, respectively.
- The research also indicated that certain lifestyle factors, like alcohol use and smoking, interact with these genetic variants to affect stroke risk, highlighting the importance of understanding these genetic markers for better risk assessment.
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