Background: Prolonged use of antibiotics may lead to the selection of drug-resistant bacteria; as a result, efforts are being made to identify new and effective antimicrobial agents, particularly, from medicinal plants, against bacterial infections. Antimicrobial activity of against has not yet been reported.
Materials And Methods: The antibacterial effect of methanol leaf extracts against (ATCC 43504) was evaluated in liquid medium by the colorimetric 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay and in solid medium by the colony forming units (CFU) method.
Results: Methanol extracts significantly (<0.05) inhibited growth in liquid medium from 24% to 82% at concentrations ranging from 31.25 mg/ml to 500 mg/ml, respectively, and in solid medium the extracts caused significant (<0.05) 52% and 100% bacterial growth inhibition at concentrations of 250 μg/mL and 500 μg/mL, respectively, as compared with untreated control. Methanol vehicle did not affect growth.
Conclusion: The observed antibacterial effect of extracts may be of benefit as an adjuvant treatment of diseases caused by .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566153 | PMC |
| http://dx.doi.org/10.21010/ajtcam.v13i4.9 | DOI Listing |
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