AI Article Synopsis
- eIF5A is a special helper protein that helps make other proteins, especially those with lots of proline, which are important for cell growth and structure.
- In fruit flies (Drosophila), eIF5A helps assemble actin cables that are crucial for proper development during a process called dorsal closure.
- The study shows that eIF5A works in similar ways across different species, helping with important jobs in cells by managing other proteins like Diaphanous that affect how cells move and form shapes.
Article Abstract
Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin involved in actin dynamics during DC, is regulated by and mediates eIF5A effects. Finally, eIF5A controls cell migration and regulates Diaphanous levels also in mammalian cells. Our results uncover an evolutionary conserved role of eIF5A regulating cytoskeleton-dependent processes through translation of formins in eukaryotes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575014 | PMC |
| http://dx.doi.org/10.1038/s41598-017-10057-y | DOI Listing |
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