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Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.
Pharmaceutics
November 2024
Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Lipid nanoparticles (LNPs) have shown promise as a delivery system for nucleic acid-based therapeutics, including DNA, siRNA, and mRNA vaccines. The immune system plays a critical role in the response to these nanocarriers, with innate immune cells initiating an early response and adaptive immune cells mediating a more specific reaction, sometimes leading to potential adverse effects. Recent studies have shown that the innate immune response to LNPs is mediated by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), which recognize the lipid components of the nanoparticles.
View Article and Find Full Text PDFShort-Term Effects of NO Exposure on Hospitalization for Chronic Kidney Disease.
Toxics
December 2024
Medical Center for Neck and Low Back Pain, Xijing Hospital, Fourth Military Medical University, Xi'an 710000, China.
This study investigates the correlation between short-term exposure to nitrogen dioxide (NO) and hospitalization for chronic kidney disease (CKD) in Lanzhou, China. A distributed lag nonlinear model (DLNM) was employed to examine the relationship between changes in NO concentration and CKD hospitalizations. Subgroup analyses were conducted to assess the sensitivity of different populations to NO exposure.
View Article and Find Full Text PDFDiscovery of Glucose Metabolism-Associated Genes in Neuropathic Pain: Insights from Bioinformatics.
Int J Mol Sci
December 2024
Department of Anesthesiology, Laboratory and Clinical Research Institute for Pain, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Metabolic dysfunction has been demonstrated to contribute to diabetic pain, pointing towards a potential correlation between glucose metabolism and pain. To investigate the relationship between altered glucose metabolism and neuropathic pain, we compared samples from healthy subjects with those from intervertebral disc degeneration (IVDD) patients, utilizing data from two public datasets. This led to the identification of 412 differentially expressed genes (DEG), of which 234 were upregulated and 178 were downregulated.
View Article and Find Full Text PDFAssessment of Facial Pain After Internal Carotid Artery Stenting: The Role of External Carotid Artery Overstenting.
J Clin Med
December 2024
Department of General Surgery, Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 45-47 Ziołowa Street, 40-635 Katowice, Poland.
: The external carotid artery (ECA) supplies blood to various facial and neck regions and may contribute to collateral cerebral perfusion. With the rise in carotid artery stenting (CAS) as a treatment for carotid stenosis, ECA overstenting has become a common procedure feature. This study aimed to assess the incidence, characteristics, and duration of facial pain following CAS, hypothesizing that ECA overstenting may contribute to facial pain.
View Article and Find Full Text PDFPrevalence of Temporomandibular Disorders in Adult Women with Endometriosis.
J Clin Med
December 2024
Faculty of Rehabilitation, Józef Piłsudski Academy of Physical Education in Warsaw, 00-968 Warsaw, Poland.
The prevalence of endometriosis varies between 10% and 18%, while temporomandibular disorders (TMDs) concern between 29 and 34% of the general population. Both conditions share similar etiological factors and symptoms such as widespread, chronic pain. Therefore, both are qualified as Chronic Overlapping Pain Conditions.
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