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Opioid reward and deep brain stimulation of the lateral hypothalamic area.
Vitam Horm
January 2025
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Opioid use disorder (OUD) is considered a global health issue that affects various aspects of patients' lives and poses a considerable burden on society. Due to the high prevalence of remissions and relapses, novel therapeutic approaches are required to manage OUD. Deep brain stimulation (DBS) is one of the most promising clinical breakthroughs in translational neuroscience.
View Article and Find Full Text PDFAn optogenetic mouse model of hindlimb spasticity after spinal cord injury.
Exp Neurol
January 2025
Brain and Mind Research Institute, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Spasticity is a common comorbidity of spinal cord injury (SCI), disrupting motor function and resulting in significant discomfort. While elements of post-SCI spasticity can be assessed using pre-clinical SCI models, the robust measurement of spasticity severity can be difficult due to its periodic and spontaneous appearance. Electrical stimulation of sensory afferents can elicit spasticity-associated motor responses, such as spasms; however, placing surface electrodes on the hindlimbs of awake animals can induce stress or encumbrance that could influence the expression of behaviour.
View Article and Find Full Text PDFA Quantitative Analysis of Internal and External Loads in Aviation Firefighting Using a Simulated Scenario.
Healthcare (Basel)
January 2025
Biomechanics, Physical Performance, and Exercise Research Group, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2000, Australia.
Background/objectives: Aviation firefighting is a strenuous occupation that requires individuals to engage in intense physical activity amidst elevated stress levels and extreme environmental conditions. Despite this, there has been limited investigation regarding the internal and external loads associated with aviation firefighting tasks, which include hose dragging, stair climbing, casualty evacuation, and fire extinguishing in airports and aircrafts. The aim of this study was to examine the internal and external loads placed on aviation firefighters.
View Article and Find Full Text PDFTime to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia.
BMC Infect Dis
January 2025
Department of Midwifery, College of Health Sciences, Salale University, Fiche, Ethiopia.
Background: Neonatal sepsis remains one of the most common causes of morbidity and mortality among neonates in developing countries. It can cause severe morbidities and sequelae, even though patients survive. Prolonged recovery time of neonatal sepsis leads to hospitalization, increased cost of treatments, antimicrobial resistance, disseminated intravascular coagulation, respiratory failure, septic shock, brain lesions, renal failure, and cardiovascular dysfunction, and eventually death.
View Article and Find Full Text PDFPhysical demands and physiological response of soccer referees in high-level matches: A systematic review.
PLoS One
January 2025
China Football Academy, Beijing Sport University, Beijing, China.
Background: The match physical demands placed on soccer referees are intrinsically connected to their capacity to make accurate judgments, becoming the second most studied theme in associate soccer refereeing.
Objective: This study aims to review the external and internal load performed by soccer referees in high-level competitions, to identify changes in these indicators over different periods as the competition progresses, and to analyze the standards for dividing speed zones and heart rate zones.
Methods: Web of Science, PubMed, Scopus, and EBSCOhost were thoroughly searched.
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