AI Article Synopsis
- Enzyme levels of monoamine oxidase, diamine oxidase, and lysyl oxidase-like activity were measured in patients with granuloma annulare, necrobiosis lipoidica, and diabetes mellitus, showing significant increases in diabetes and necrobiosis lipoidica but only minor changes in granuloma annulare.
- The findings suggest a potential link between "stiff" collagen and these disorders, indicating that amine oxidases could help monitor collagen abnormalities in diabetes-related conditions.
- A negative correlation between enzyme activity and blood glucose suggests that collagen changes might happen independently of blood sugar levels, indicating a need to further explore the role of these enzymes in related complications like angiopathy.
Article Abstract
Serum monoamine oxidase, diamine oxidase and lysyl oxidase-like activity were measured in patients with granuloma annulare (GA), necrobiosis lipoidica (NL) and diabetes mellitus. In diabetes, all enzyme measurements were raised by a factor of about 2 X 2, and in NL by a factor of about 1 X 5. The rise in patients with GA was small and only significant in the case of benzylamine monoamine oxidase. "Stiff' collagen would seem to link these three disorders and the present results suggest that these amine oxidases could be useful in monitoring collagen abnormality in diabetes and diabetes-associated disorders, particularly in the absence of chronic liver disease. A negative correlation was found between enzyme activity and blood glucose levels, thus collagen changes in these conditions may occur independently of elevated blood glucose levels. Possible involvement of these enzymes in angiopathy remains to be elucidated.
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| http://dx.doi.org/10.1111/j.1365-2133.1987.tb05897.x | DOI Listing |
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