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| http://dx.doi.org/10.15326/jcopdf.4.3.2017.0154 | DOI Listing |
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Automated CT-based measurements of radial and longitudinal expansion of airways due to breathing-related lung volume change.
Med Phys
December 2024
Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Background: Respiratory function is impaired in chronic obstructive pulmonary disease (COPD). Automation of multi-volume CT-based measurements of different components of breathing-related airway deformations will help understand multi-pathway impairments in respiratory mechanics in COPD.
Purpose: To develop and evaluate multi-volume chest CT-based automated measurements of breathing-related radial and longitudinal expansion of individual airways between inspiratory and expiratory lung volumes.
Metabolic pathways from the gut metatranscriptome are associated with COPD and respiratory function in lung cancer patients.
Front Cell Infect Microbiol
December 2024
Translational Medicine Institute, Semmelweis University, Budapest, Hungary.
Introduction: Changes in the human gut microbiome have been linked to various chronic diseases, including chronic obstructive pulmonary disease (COPD). While substantial knowledge is available on the genomic features of fecal communities, little is known about the microbiome's transcriptional activity. Here, we analyzed the metatranscriptomic (MTR) abundance of MetaCyc pathways, SuperPathways, and protein domain families (PFAM) represented by the gut microbiome in a cohort of non-small cell lung cancer (NSCLC) patients with- or without COPD comorbidity.
View Article and Find Full Text PDFPulmonary Xe MRI: CNN Registration and Segmentation to Generate Ventilation Defect Percent with Multi-center Validation.
Acad Radiol
November 2024
Robarts Research Institute, Western University, London, Canada; School of Biomedical Engineering, Western University, London, Canada; Department of Medical Biophysics, Western University, London, Canada; Division of Respirology, Department of Medicine, Western University, London, Canada. Electronic address:
Rationale And Objectives: Hyperpolarized Xe MRI quantifies ventilation-defect-percent (VDP), the ratio of Xe signal-void to the anatomic H MRI thoracic-cavity-volume. VDP is associated with airway inflammation and disease control and serves as a treatable trait in therapy studies. Semi-automated VDP pipelines require time-intensive observer interactions.
View Article and Find Full Text PDFThe Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report.
Ann Am Thorac Soc
November 2024
Icahn School of Medicine at Mount Sinai, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York, New York, United States;
The prevalence of obstructive sleep apnea (OSA) is on the rise, driven by various factors including more sensitive diagnostic criteria, increased awareness, enhanced technology through at-home testing enabling easy and cost-effective diagnosis, and a growing incidence of comorbid conditions such as obesity. Treating symptomatic patients with OSA syndrome to enhance quality of life remains a cornerstone approach. However, there is a lack of consensus regarding treatment to improve cardiovascular disease (CVD) outcomes, particularly in light of overall negative results from several randomized controlled trials (RCT) indicating no benefit of positive airway pressure (PAP) therapy on primary and secondary CVD events.
View Article and Find Full Text PDFMulti-Omics Analysis Identified Drug Repurposing Targets for Chronic Obstructive Pulmonary Disease.
Int J Mol Sci
October 2024
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Despite recent advances in chronic obstructive pulmonary disease (COPD) research, few studies have identified the potential therapeutic targets systematically by integrating multiple-omics datasets. This project aimed to develop a systems biology pipeline to identify biologically relevant genes and potential therapeutic targets that could be exploited to discover novel COPD treatments via drug repurposing or drug discovery. A computational method was implemented by integrating multi-omics COPD data from unpaired human samples of more than half a million subjects.
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