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| http://dx.doi.org/10.1159/000453071 | DOI Listing |
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Perforated Jejunal Diverticulitis: Surgical and Antibiotic Management.
Cureus
August 2024
Internal Medicine, Crestwood Medical Center, Huntsville, USA.
Small bowel diverticulitis occurs at a rate of 0.06% to 1.3%, mainly in individuals over 50, peaking between ages 60 and 70.
View Article and Find Full Text PDFNeurofibromatosis Type 1 Presenting as Bleeding Jejunal Gastrointestinal Stromal Tumour.
Case Rep Gastroenterol
June 2024
Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore, Singapore.
Introduction: Gastrointestinal stromal tumours (GISTs) are an important, though uncommon, cause of obscure gastrointestinal bleeding and may rarely be associated with genodermatoses such as neurofibromatosis type 1 (NF1). NF1-related GISTs have unique phenotypic features compared with sporadic GISTs and may elude diagnosis due to their predilection for the small bowel.
Case Presentation: We report a case of a 45-year-old Singaporean woman with café-au-lait macules and cutaneous neurofibromas who presented with occult obscure gastrointestinal bleeding and was eventually discovered to have a bleeding jejunal GIST.
Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition.
J Virol
July 2024
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Article Synopsis
- Human noroviruses (HuNoVs) are RNA viruses responsible for acute gastroenteritis, and many strains, like GII.3, require bile acids (BA) for infection in intestinal cells.
- The study found that inhibiting the S1PR2 receptor reduces GII.3 infection, indicating that this receptor plays a crucial role in the infection process across different strains and segments of the small intestine.
- Results showed that while GII.3 and other BA-dependent strains rely on S1PR2 for infection, the GII.4 strain does not, highlighting strain-specific mechanisms in HuNoV infection.
Case Report: Robotic pylorus-preserving pancreatoduodenectomy for periampullary rhabdomyosarcoma in a 3-year-old patient.
Front Surg
February 2024
Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Periampullary neoplasm is rare in pediatric patients and has constituted a strict indication for pancreatoduodenectomy (PD), which is a procedure sporadically reported in the literature among children. Robotic PD has been routinely performed for periampullary neoplasm in periampullary neoplasm, but only a few cases in pediatric patients have been reported. Here, we report the case of a 3-year-old patient with periampullary rhabdomyosarcoma treated with robotic pylorus-preserving PD and share our experience with this procedure in pediatric patients.
View Article and Find Full Text PDFArticle Synopsis
- Human noroviruses (HuNoVs) are diverse RNA viruses that cause viral gastroenteritis, with some strains needing bile acids (BA) for infection, while others, like the pandemic GII.4, do not.
- In this study, the researchers examined the role of the G-protein coupled receptor S1PR2 in the infection process of various HuNoV strains, discovering that inhibiting S1PR2 reduced the infection of BA-dependent strains but not BA-independent strains like GII.4.
- The findings suggest that BA-dependent HuNoVs use S1PR2 activation to infect different segments of the small intestine, highlighting the complexity of norovirus infections and the potential for strain-specific targeting in treatment.
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