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Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.
Front Med (Lausanne)
December 2024
Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.
POEMS syndrome is a complex and rare hematological disease involving multiple physiological systems. According to the currently accepted diagnostic criteria for POEMS syndrome, polyneuropathy is one of the primary mandatory criteria. A patient presented with M protein, Castleman disease (CD), elevated vascular endothelial growth factor (VEGF), extravascular volume overload, and endocrinopathy.
View Article and Find Full Text PDFOptimal Cutoff Values and Utility of High-Sensitivity Troponin T and NT-proBNP for the Risk Stratification of Patients with Acute Pulmonary Embolism.
Clin Chem
December 2024
Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States.
Background: Guidelines recommend using high-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to risk stratify hemodynamically stable patients with acute pulmonary embolism (PE). However, there are no evidence-based cutoff values defined for this clinical application.
Methods: We performed a single-center, retrospective cohort study of patients with imaging-confirmed PE and hsTnT and/or NT-proBNP (ElecsysTM, Roche) measured 12 h before or 24 h after PE Response Team (PERT) activation.
Pancreatic Heterotopia Presenting as a Mimic of Fistulizing Crohn's Disease: Expanding the Differential Diagnosis of Inflammatory Bowel Disease.
Cureus
September 2024
Pathology, Tower Health Reading Hospital, West Reading, USA.
Article Synopsis
- Pancreatic heterotopia (PH) refers to the presence of pancreatic tissue in locations outside its normal site, usually without any connection to the pancreas, and is typically asymptomatic.
- Symptoms, when they occur, can resemble those of Crohn's disease, including abdominal pain, nausea, and diarrhea, and often manifest in adulthood.
- A case study revealed a patient initially diagnosed with Crohn's disease, who later had surgery that identified ectopic pancreatic tissue as the underlying cause of her gastrointestinal symptoms, which resolved after resection.
Bridging the Diagnostic Gap for Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Evidence of a Common Extracellular Matrix Fragmentation Pattern in Patient Plasma as a Potential Biomarker.
Am J Med Genet A
January 2025
Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, European Network for Rare Skin Disorders (ERN-Skin), Brescia, Italy.
Diagnosing hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD), common overlapping multisystemic conditions featuring symptomatic joint hypermobility, is challenging due to lack of established causes and diagnostic tools. Currently, the 2017 diagnostic criteria for hEDS are used, with non-qualifying cases classified as HSD, although the distinction remains debated. We previously showed extracellular matrix (ECM) disorganization in both hEDS and HSD dermal fibroblasts involving fibronectin (FN), type I collagen (COLLI), and tenascin (TN), with matrix metalloproteinase-generated fragments in conditioned media.
View Article and Find Full Text PDFAnti-VEGF Pharmaceutical Prior Authorization in Retina Practices.
JAMA Ophthalmol
August 2024
Retina Consultants of Texas, Houston.
Importance: Anti-vascular endothelial growth factor (VEGF) intravitreal injections, a mainstay of treatment for many retinal diseases to optimize visual outcomes, have been included in prior authorization (PA) initiatives. However, if clinicians are extremely accurate in their use of anti-VEGF medications, such administrative burdens may need reconsideration.
Objective: To quantify PA for anti-VEGF medications (aflibercept, ranibizumab, and bevacizumab) that were approved and determine associated administrative burdens experienced by retina practices.
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