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The Association Between the rs2200733 SNP and Atrial Fibrillation Among Arabs: A Study from Jordan.
Biologics
December 2024
Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Introduction: Atrial fibrillation (AFib) is a common disorder featured by an irregular and fast heartbeat. The etiology of AFib is complex and involves genetic and environmental factors. The rs2200733 single nucleotide polymorphism (SNP) is located in close proximity to the promoter of paired-like homeodomain transcription factor 2 (PITX2) which plays a role in heart development.
View Article and Find Full Text PDFComparison of Basal Core Promoter Region Mutation and Precore Mutation among Monoinfected Hepatitis B Virus and Coinfected Hepatitis B Virus with Human Immunodeficiency Virus Patients.
J Assoc Physicians India
December 2024
Assistant Professor, Department of Microbiology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India, Corresponding Author.
Objectives: Hepatitis B virus (HBV) has a partially double-stranded circular deoxyribonucleic acid (DNA) that replicates through reverse transcription, producing an intermediate ribonucleic acid (RNA). This replication process has a high chance of error, leading to several mutations in the genome. According to several studies conducted worldwide, the classical basal core promoter (BCP) double mutation (A to T at nucleotide 1762 and G to A at nucleotide 1764) in the BCP region and the mutation in the precore (PC) region (G to A at nucleotide 1896) of HBV DNA have a strong correlation with advanced liver disease.
View Article and Find Full Text PDFand markers of resistance to sulfadoxine-pyrimethamine five years (2016-2020) after the implementation of seasonal malaria chemoprevention in Cameroon.
Wellcome Open Res
June 2024
MARCAD Program, The biotechnology Centre, University of Yaounde I, Yaounde, Centre, P 0 Box 8094, Cameroon.
Background: Antimalarial drug resistance is a major challenge in the fight against malaria. Cameroon implemented seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SPAQ) to over 1.5 million children aged 3-59 months from 2016, raising concerns whether drug pressure may lead to a selection of known parasite resistance mutations.
View Article and Find Full Text PDFLncRNA gene polymorphisms and their influence on lung cancer patients in the Chinese Han population.
Noncoding RNA Res
February 2025
School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.
Article Synopsis
- Lung cancer is mainly categorized as NSCLC, with a focus on an unexamined lncRNA and its genetic variations that may influence NSCLC susceptibility.
- The study involved 700 NSCLC patients and 700 healthy controls, utilizing methods like PCR-RFLP to analyze the connection between specific genetic polymorphisms and lung cancer risk.
- Results indicate that higher expression of the lncRNA in lung adenocarcinoma tissues correlates with cancer progression, and a specific genotype (rs3806609 TT) increases susceptibility to NSCLC, suggesting potential markers for targeted therapy.
Molecular analysis of vector-borne pathogens in Eurasian badgers (Meles meles) from continental Europe.
Parasit Vectors
November 2024
Institute of Parasitology, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Article Synopsis
- * Researchers collected blood or spleen samples from 220 badgers in nine countries between 2017 and 2021 and used PCR analysis and sequencing to identify various VBPs present in the animals.
- * Key findings revealed the presence of several pathogens, including different types of Babesia, Trypanosoma pestanai, and Mycoplasma, while Rickettsia, Bartonella, and filarioid nematodes were not detected.
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