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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617673 | PMC |
| http://dx.doi.org/10.1172/JCI97015 | DOI Listing |
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A single G protein-coupled receptor (GPCR) can activate multiple signaling cascades based on the binding of different ligands. The biological relevance of this feature in immune regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines: CXCL9, CXCL10, and CXCL11.
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