Context: Heat generation by brown adipose tissue (BAT) in response to temperature reduction seems to be entirely related to sympathetic nervous stimulation.
Objective: To analyse if temperature reduction and norepinephrine may differently affect the expression of proteins related to energy metabolism in BAT.
Materials And Methods: Isolated rats BAT was incubated with/without norepinephrine (10 mol/L, 24 h at 32 °C and 37 °C).
Results: In BAT, 32 °C increased the protein expression levels of carnitine palmitoyltransferase-I and -II, mitochondrial uncoupling protein-1 (UCP-1) and the expression and activity of lactate dehydrogenase. Mitochondrial F-ATP synthase α-chain expression was decreased at 32 °C compared to 37 °C. Norepinephrine and at 32 °C exposure, UCP-1 expression was increased but cytochrome-c oxidase and F-ATP synthase α-chain expression was reduced with respect to 37 °C.
Discussion: Sympathetic stimulation seems not to be the only factor associated with heat generation.
Conclusions: Temperature reduction by itself exerts some different effects on the expression of proteins related to the energy metabolism than norepinephrine.
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