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Genital herpes zoster-an unusual but important cause of acute nontraumatic vulvar ulcers.
Am J Obstet Gynecol
December 2024
Gaia/Espinho Local Health Unit, Department of Obstetrics and Gynecology, Vila Nova de Gaia, Portugal; CINTESIS - Center for Health Technology and Services Research, University of Port, Porto, Portugal; Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Genital Herpes Zoster: A Report of a Rare Case.
Cureus
October 2024
Department of Obstetrics and Gynecology, General Hospital of Lamia, Lamia, GRC.
Herpes zoster (HZ), caused by the reactivation of the varicella-zoster virus (VZV), typically presents as a unilateral vesicular rash in a dermatomal pattern. Its occurrence in the genital area is rare and often misdiagnosed. We report the case of a 51-year-old woman who presented with sudden vulvar pain and burning, without a history of immunodeficiency or sexually transmitted infections.
View Article and Find Full Text PDFA nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion.
PLoS Pathog
September 2024
Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Article Synopsis
- The effectiveness of HSV-2 vaccine candidates in mice and guinea pigs hasn't been reliably predictive for human trials, prompting researchers to look for better animal models.
- Cebus apella monkeys were evaluated in an HSV-2 genital infection model, where they developed antibodies and had some lesions, but showed potential for protective immunity after primary infection.
- The study suggests that C. apella may be a more appropriate model for testing HSV-2 vaccines and treatments compared to other primates like rhesus macaques, owing to their ability to support virus growth and develop immune responses.
Genital VZV in a Third Trimester Pregnancy and the Critical Role of Interdisciplinary Planning.
Case Rep Infect Dis
April 2024
School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Article Synopsis
- Herpes simplex (HSV) and varicella zoster (VZV) are serious concerns during pregnancy due to their potential to harm both mother and baby through direct infection and complications.
- A case involving a 19-year-old pregnant woman with VZV symptoms was successfully treated with acyclovir, leading to a healthy delivery.
- It is crucial to investigate genital lesions for VZV in pregnant patients, especially those lacking immunity, to develop effective management and ensure safety for mother and baby during childbirth.
A real-world pharmacovigilance analysis of FDA adverse event reporting system database for upadacitinib.
Front Pharmacol
August 2023
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
To mine the adverse drug event (ADE) signals of upadacitinib based on the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to provide a reference for the safe clinical use of the drug. The ADE data for upadacitinib from Q1 2004 to Q1 2023 in the FAERS database were retrieved, and data mining was performed using the reporting odds ratio and proportional reporting ratio. A total of 21,213 ADE reports for the primary suspect drug upadacitinib were obtained, involving 444 ADEs.
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