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Microvesicle Tissue Factor Procoagulant Activity Is Elevated and Correlated With Disease Severity in Patients With Cirrhosis.
Liver Int
November 2024
Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.
Background And Aims: Tissue factor-expressing microvesicles (MV-TF) have been found to correlate with thrombotic complications in various diseases. Simultaneously, there is expanding research regarding the effect of the coagulation cascade on liver fibrosis progression. The aim of our manuscript was to evaluate MV-TF activity in patients with cirrhosis and its correlation with disease severity.
View Article and Find Full Text PDFEvaluating the Effectiveness of Enoxaparin in Treating Pediatric Arterial Thrombosis in Saudi Arabia.
Children (Basel)
September 2024
Pharmaceutical Practices Department, College of Pharmacy, Umm Al-Qura University, Makkah 24381, Saudi Arabia.
Background: Thrombosis is the abnormal formation of blood clots within blood vessels; it results from an imbalance between fibrinolytic, pro-coagulant, and anticoagulant systems. Pediatric arterial thrombosis, especially related to catheter usage, is an emerging issue with limited evidence. This study evaluates the efficacy of enoxaparin in treating arterial thrombosis in pediatric patients at a single center.
View Article and Find Full Text PDFA loss of tuning of both pro-coagulant and inflammatory responses in monocytes in patients with preeclampsia.
J Reprod Immunol
December 2024
Department of Immunology, Yamagata University Faculty of Medicine, Yamagata, Japan.
An imbalance between pro- and anti-angiogenesis is one of the leading causes of preeclampsia (PE). Monocytes, known as regulators of angiogenesis during immune responses, cooperate with platelets, but the specifics of these responses during pregnancy remain unclear. In this study, we investigated the relationship between pro-coagulant responses on monocytes [platelet activation marker CD61 as a monocyte-platelet aggregate (MPA), tissue factor (CD142), etc.
View Article and Find Full Text PDFPromoted coagulant activity and disrupted blood-brain barrier depending on phosphatidylserine externalization of red blood cells exposed to ZnO nanoparticles.
Environ Pollut
December 2024
College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, Republic of Korea. Electronic address:
Article Synopsis
- Zinc oxide nanoparticles (ZnO-NPs) are widely used nanomaterials that can enter the bloodstream, raising concerns about their impact on cardiovascular health.
- The study found that ZnO-NPs can increase clotting activity in red blood cells and disrupt the blood-brain barrier by promoting the engulfment of these cells by brain endothelial cells.
- These effects suggest that ZnO-NPs could pose potential risks for thrombosis and cardiovascular dysfunction, highlighting the need for further investigation into their safety.
Testosterone Therapy Does Not Affect Coagulation in Male Hypogonadism: A Longitudinal Study Based on Thrombin Generation.
J Clin Endocrinol Metab
November 2024
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Context: Testosterone therapy has been variably associated with increased thrombotic risk but investigations of global coagulation in this setting are lacking.
Objective: This work aimed to compare global coagulation of hypogonadal men before (T0) and 6 months after (T1) starting testosterone replacement therapy (TRT), and healthy controls (HCs).
Methods: An observational prospective cohort study was conducted at 2 tertiary endocrinological ambulatory care centers.
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