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Silent Inflammation: A Case of Blurry Vision Raising Diagnostic Challenges in an Elderly Patient.
Cureus
November 2024
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Stony Brook University Hospital, Stony Brook, USA.
Giant cell arteritis (GCA) is a large vessel vasculitis with cranial and extracranial vessel involvement. Clinicians suspect GCA when a patient exhibits symptoms or exam findings of temporal headache with sudden vision loss, jaw or tongue claudication, scalp tenderness, abnormal temporal artery exam, and diagnostic findings, including elevated inflammatory markers. We present a case, which highlights that, despite established diagnostic measures, challenges persist.
View Article and Find Full Text PDFGiant cell arteritis following SARS-CoV-2 infection.
BMJ Case Rep
December 2024
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
Giant cell arteritis (GCA) is a vasculitis characterised by arterial inflammation, with permanent vision loss being a feared complication. The association between GCA and viral infections is well-known, but there is limited data regarding its relationship to COVID-19. A man in his 80s with a recent history of COVID-19 developed sudden vision loss, persistent headaches and jaw claudication.
View Article and Find Full Text PDFFrench protocol for the diagnosis and management of giant cell arteritis.
Rev Med Interne
October 2024
Department of Internal Medicine and Clinical Immunology, Referral Centre for Rare Systemic Autoimmune and Autoinflammatory Diseases (MAIS), Dijon Bourgogne University Hospital, Dijon, France; Inserm, EFS BFC, UMR 1098, RIGHT Graft-Host-Tumour Interactions/Cellular and Genetic Engineering, Bourgogne Franche-Comté University, Dijon, France. Electronic address:
Article Synopsis
- Giant cell arteritis (GCA) primarily affects women over 50, causing symptoms like headaches and jaw pain, and can lead to severe complications like vision loss due to eye involvement.
- Diagnosis relies on advanced imaging techniques such as FDG-PET and CT scans, while the temporal artery biopsy is considered the gold standard.
- Urgent treatment with high doses of corticosteroids is critical to prevent vision loss, and long-term management is necessary to monitor for recurrence and potential cardiovascular issues.
Ultrasound in GCA: Halo Sign Quantification and Visual Symptoms, Systemic Inflammation and Relapse Risk.
Mediterr J Rheumatol
September 2024
Department of Rheumatology, Dudley Group NHS Foundation Trust, United Kingdom.
Background: A sonographic scoring system, termed Halo count and Halo score, of temporal and axillary arteries (TAXA) in suspected giant cell arteritis (GCA) has been proposed for outcome prognostication.
Method: We conducted a retrospective review into the relationship of Halo count and Halo score and clinical-laboratory parameters amongst patients diagnosed with GCA via our rapid-access pathway to determine whether these measures should form part of our local routine clinical practice.
Result: This review of TAXA ultrasound (US) images in patients with diagnosed GCA did not identify any correlation between Halo count/score and ocular symptoms, jaw claudication, 6-month relapse risk or inflammatory markers.
Inflammation of the temporalis muscle and adjacent nerve tissue in giant cell arteritis: expanding the spectrum of inflammatory lesions.
Rheumatology (Oxford)
October 2024
Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.
Objectives: To investigate the histopathological features of the temporalis muscle (TM) and adjacent nerve tissue in active cranial giant cell arteritis (C-GCA).
Methods: Temporal artery biopsy (TAB) specimens containing fragments of the TM from patients with active C-GCA fulfilling the 2022 ACR/EULAR classification criteria (n = 11) were assessed by conventional histology and immunohistochemistry in comparison with non-GCA controls (n = 3). Clinical, laboratory and imaging features based on patient charts at time of biopsy were retrospectively recorded.
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