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A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.
Nucleic Acid Ther
December 2024
Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Daejeon, Republic of Korea.
Article Synopsis
- - The study evaluates the reproductive safety of ISIS 838707, a specialized drug targeting mouse Apolipoprotein C-III (ApoC-III) mRNA, through analysis of fertility and developmental endpoints in male and female mice during critical life stages.
- - It found that the treatment, given at various doses, significantly reduced cholesterol and triglyceride levels while effectively lowering ApoC-III mRNA without causing overt toxicity or negative effects on reproduction.
- - The majority of the drug was concentrated in the liver, with minimal transfer to the placenta and none to developing fetuses, indicating that ISIS 838707 does not adversely affect reproductive or developmental functions in mice.
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA.
Toxicol Sci
September 2024
Toxicology Directorate, Defense Centers for Public Health-Aberdeen, Aberdeen Proving Ground, MD 21010, United States.
Perfluorononanoic acid (PFNA) is a commercially relevant, long-chain (8 fully fluorinated carbon) perfluorinated carboxylic acid. PFNA has limited terrestrial ecotoxicity data and is detected in humans, animals, and the environment. This study is the fourth in a series with the objective of investigating the toxicity of a suite of per- and polyfluoroalkyl substances (PFAS) detected on military installations in a mammal indigenous to North America.
View Article and Find Full Text PDFDietary hydrolyzed soya lecithin affects feed intake, abundance of bacteria in the caecum, fatty acid composition and area of adipocytes in pre-mating primiparous V-line female rabbit.
J Anim Physiol Anim Nutr (Berl)
May 2024
Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
This study aimed at investigating the effect of hydrolyzed soya lecithin; also called lysolecithin or lysophosphatidylcholine, on growth performance, caecal microbiota and fat depots in pre-breeding primiparous rabbits does. For this, 60 V-Line primiparous rabbits does (5-6 months) were used in a 30-day experiment. Does were allotted into three iso-nitrogenous iso-caloric dietary treatments (n = 20/group) as follows: (1) CON received 0% soya lecithin, (2) LECL group was fed a basal diet supplemented with 0.
View Article and Find Full Text PDFEffects of and concentrate mixed supplements on reproductive performance and pre-weaning growth of Horro sheep grazing natural pasture in Ethiopia.
Vet Anim Sci
March 2023
Bako Agricultural Research Center, P. O. Box 03, Bako, Ethiopia.
The goal of this study was to compare the productivity and reproduction of Horro ewes treated with concentrate supplements (T1), and Gebis-17 (T2) and Beresa-55 (T3) varieties. Horro ewes (n = 21, 7 ewes per treatment) with a mean premating weight of 26.3 + 2.
View Article and Find Full Text PDF<b>Background and Objective:</b> There is very rare information regarding data of reproduction performance of small ruminant with different management flushing program in Asian countries. The aim of this study was to evaluate the implementation of flushing diet program containing lemuru fish oil with time management difference, by evaluating the reproductive performance of local Garut ewes. <b>Materials and Methods:</b> Twenty of garut ewes (average body weight 30.
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