Objectives: The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer F-fluciclovine (anti-[F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.
Methods: Anti-[F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET imaging. T1-weighted, contrast-enhanced T1-weighted, and fluid-attenuated inversion recovery (or T2-weighted) magnetic resonance imaging (MRI) scans were obtained to plan for the tissue collection. Tissues were collected from either "areas visualized using anti-[F]FACBC PET imaging but not using contrast-enhanced T1-weighted imaging" or "areas visualized using both anti-[F]FACBC-PET imaging and contrast-enhanced T1-weighted imaging" and were histopathologically examined to assess the diagnostic accuracy of anti-[F]FACBC-PET for gliomas.
Results: The positive predictive value of anti-[F]FACBC-PET imaging for glioma in areas visualized using anti-[F]FACBC-PET imaging, but not visualized using contrast-enhanced T1-weighted images, was 100.0% (26/26), and the value in areas visualized using both contrast-enhanced T1-weighted imaging and anti-[F]FACBC-PET imaging was 87.5% (7/8). Twelve adverse events occurred in 7 (17.5%) of the 40 patients who received anti-[F]FACBC. Five events in five patients were considered to be adverse drug reactions; however, none of the events were serious, and all except one resolved spontaneously without treatment.
Conclusion: This Phase IIb trial showed that anti-[F]FACBC-PET imaging was effective for the detection of gliomas in areas not visualized using contrast-enhanced T1-weighted MRI and the tracer was well tolerated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221680 | PMC |
| http://dx.doi.org/10.22038/aojnmb.2016.7869 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative analysis of imaging and pathological features in diagnosis of endometrial carcinosarcoma based on multimodal MRI.
Arch Gynecol Obstet
January 2025
Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Purpose: This case report aims to present a rare case of endometrial carcinosarcoma, a highly malignant tumor with a poor prognosis. The primary objective is to describe this unique case's clinical presentation, multimodal magnetic resonance imaging (MRI) features, typical histopathological characteristics and surgical treatment.
Methods: A detailed analysis of the patient's medical history, preoperative imaging evaluation, and treatment approach was conducted.
Accelerated High-resolution T1- and T2-weighted Breast MRI with Deep Learning Super-resolution Reconstruction.
Acad Radiol
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (N.M., C.L., A.S., A.I., T.D., L.B., D.K., C.C.P., A.L., J.A.L.).
Rationale And Objectives: To assess the performance of an industry-developed deep learning (DL) algorithm to reconstruct low-resolution Cartesian T1-weighted dynamic contrast-enhanced (T1w) and T2-weighted turbo-spin-echo (T2w) sequences and compare them to standard sequences.
Materials And Methods: Female patients with indications for breast MRI were included in this prospective study. The study protocol at 1.
Comparative analysis of brain volumetric measurements between contrast-enhanced and non-contrast MRI images.
Neurosci Lett
January 2025
Max Super Speciality Hospital, Saket, New Delhi, India. Electronic address:
Background: Clinical brain MRI scans, including contrast-enhanced (CE-MR) images, represent an underutilized resource for neuroscience research due to technical heterogeneity.
Purpose: To evaluate the reliability of morphometric measurements from CE-MR scans compared to non-contrast MR (NC-MR) scans in normal individuals.
Methods: T1-weighted CE-MR and NC-MR scans from 59 normal participants (aged 21-73 years) were compared using CAT12 and SynthSeg+ segmentation tools.
Ferumoxytol-enhanced MRI of retroplacental clear space disruption in placenta accreta spectrum.
Placenta
January 2025
Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA; The Singleton Department of Radiology, Texas Children's Hospital, Houston, TX, 77030, USA. Electronic address:
Introduction: Placenta accreta spectrum (PAS) occurs when the placenta is pathologically adherent to the myometrium. An intact retroplacental clear space (RPCS) is a marker of normal placentation. In this study, we investigate use of the FDA-approved iron supplement ferumoxytol for contrast-enhanced MRI of the RPCS in mouse models of normal pregnancy and PAS.
View Article and Find Full Text PDFKnowledge discovery from database: MRI radiomic features to assess recurrence risk in high-grade meningiomas.
BMC Med Imaging
January 2025
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Purpose: We used knowledge discovery from radiomics of T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (T1C) for assessing relapse risk in patients with high-grade meningiomas (HGMs).
Methods: 279 features were extracted from each ROI including 9 histogram features, 220 Gy-level co-occurrence matrix features, 20 Gy-level run-length matrix features, 5 auto-regressive model features, 20 wavelets transform features and 5 absolute gradient statistics features. The datasets were randomly divided into two groups, the training set (~ 70%) and the test set (~ 30%).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!