Aims: To assess whether circulating 25-hydroxyvitamin D (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease.
Methods: We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained.
Results: We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg/dL) product was positively associated with the presence of carotid plaques (OR = 1.078; 95% CI: 1.017-1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) ( ± SE = -0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559910 | PMC |
| http://dx.doi.org/10.1155/2017/3498368 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bacterial activation level determines Cd(II) immobilization efficiency by calcium-phosphate minerals in soil.
J Hazard Mater
January 2025
National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:
Soil mineral properties significantly influence the mobility of Cd(II) within the soil matrix. However, the limited understanding of how microbial metabolism affects mineral structure at the microscale poses challenges for in situ remediation. Here, we designed a model calcium-phosphate system in a urea-rich environment to explore the impact of different microbial activation levels on Cd(II) fixation at mineral interfaces.
View Article and Find Full Text PDFPrimary Neuronal Culture and Transient Transfection.
Bio Protoc
January 2025
Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Primary neuronal culture and transient transfection offer a pair of crucial tools for neuroscience research, providing a controlled environment to study the behavior, function, and interactions of neurons in vitro. These cultures can be used to investigate fundamental aspects of neuronal development and plasticity, as well as disease mechanisms. There are numerous methods of transient transfection, such as electroporation, calcium phosphate precipitation, or cationic lipid transfection.
View Article and Find Full Text PDFArthroscopic Humeroplasty in the Treatment of Acute Reverse Hill-Sachs Lesion Associated With Posterior Shoulder Instability.
Cureus
December 2024
Orthopaedics and Traumatology, Unidade Local de Saúde de Viseu Dão-Lafões, Viseu, PRT.
Reverse Hill-Sachs lesions (RHSL) are common complications associated with posterior shoulder dislocations and represent a significant challenge for preserving joint stability and function. If untreated, these compression fractures of the anteromedial humeral head can compromise the integrity of the joint, predisposing patients to recurrent instability and arthropathy. While various treatment modalities exist, achieving an anatomic reduction of the defect while preserving the articular cartilage remains a desirable outcome, particularly in acute settings.
View Article and Find Full Text PDFCorrection: Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects.
J Nanobiotechnology
January 2025
Orthodontic Department, Nanjing Stomatological Hospital, Affiliated hospital of Medical School, Institute of Stomatology, Nanjing University, No. 30 Zhongyang Road, Nanjing, Jiangsu, China.
Early osteogenic differentiation of human dental stem cells by gelatin/calcium phosphate- Punica granatum nanocomposite scaffold.
BMC Biotechnol
January 2025
Department of Oral Science and Translation Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314, USA.
Background: Tissue engineering for bone regeneration aims to heal severe bone injuries. This study aimed to prepare and assess the early osteogenic differentiation effects of a gelatin/calcium phosphate- Punica granatum nanocomposite scaffold on stem cells from human exfoliated deciduous (SHED) and human dental pulp stem cells (HDPSCs).
Methods: The electrospinning method was used to prepare a gelatin/calcium phosphate nanocomposite scaffold containing pomegranate (Punica granatum) extract.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!