AI Article Synopsis
- The study investigated how two genes regulated by the same hormones change during fetal and newborn rat liver development.
- Both the mRNA levels and transcription of tyrosine aminotransferase were low throughout pregnancy but spiked significantly at birth.
- In mutant mice lacking the ability to activate aminotransferase transcription, gene 33's activation remained unaffected, suggesting that different mechanisms control the developmental activation of these genes despite their hormonal regulation.
Article Abstract
Developmental changes in expression of two genes subject to identical hormonal controls in adult liver were examined in livers of fetal and newborn rats. Both mRNA concentrations and transcription of tyrosine aminotransferase were very low throughout gestation and increased sharply at birth. The mRNA of gene 33 (Lee et al., J. Biol. Chem. 260: 16433-16438, 1985) and its transcription were also low in fetal liver until a significant increase occurred just prior to birth, followed by a further increase at birth. In mutant mice carrying a deletion that prevents developmental activation of aminotransferase transcription, that of gene 33 was not affected. The data indicate that different mechanisms control developmental activation of these genes, in contrast to hormonal regulation of their expression.
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| http://dx.doi.org/10.1016/0006-291x(87)91436-7 | DOI Listing |
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