Understanding the dynamic behaviour of the Plasmodium falciparum metabolism during infection can help identify targets for drug development. In this Commentary, we highlight recently published studies in The FEBS Journal that cover mathematical modelling of glycolysis in P. falciparum and the identification and in vivo validation of metabolic drug targets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/febs.14161 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.
Nat Commun
December 2024
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P.
View Article and Find Full Text PDFPrevalence of Acute Kidney Injury (AKI) in Children with Severe Malaria Using a Novel Biomarker: Serum NGAL in Enugu.
West Afr J Med
August 2024
Department of Paediatrics, College of Medicine UNEC, Enugu, Enugu State, Nigeria Tel: +234 8034710392, Email:
Objectives: This study aims to determine the prevalence of Acute Kidney Injury (AKI) among children with severe malaria who present to the emergency room, using serum creatinine and NGAL levels as biomarkers. It also aims to ascertain which biomarker (serum creatinine and NGAL) detects AKI earliest, especially at day 0. The study is also aims to determine the relationship between parasite density and levels of serum NGAL.
View Article and Find Full Text PDFPrevalence of Acute Kidney Injury (AKI) in Children with Severe Malaria Using a Novel Biomarker: Serum Neutrophil Gelatinase Associated Lipocalin (NGAL) in Enugu.
West Afr J Med
August 2024
Department of Paediatrics, College of Medicine UNEC, Enugu, Enugu State, Nigeria Tel: +234 8034710392, Email:
Objectives: This study aims to determine the prevalence of Acute Kidney Injury (AKI) among children with severe malaria who present to the emergency room, using serum creatinine and NGAL levels as biomarkers. It also aims to ascertain which biomarker (serum creatinine and NGAL) detects AKI earliest, especially at day 0. The study is also aims to determine the relationship between parasite density and levels of serum NGAL.
View Article and Find Full Text PDFGenetic factors regulating Plasmodium falciparum gametocytogenesis identified by phenotypic screens.
Sci Rep
December 2024
Center for Global Health and Inter-Disciplinary Research, College of Public Health, University of South Florida, Tampa, FL, USA.
Successful transmission of Plasmodium falciparum from one person to another relies on the complete intraerythrocytic development of non-pathogenic sexual gametocytes infectious for anopheline mosquitoes. Understanding the genetic factors that regulate gametocyte development is vital for identifying transmission-blocking targets in the malaria parasite life cycle. Toward this end, we conducted a forward genetic study to characterize the development of gametocytes from sexual commitment to mature stage V.
View Article and Find Full Text PDFCharacterization of serological responses to Plasmodium falciparum (Pf) is of interest to understand disease burden and transmission dynamics; however, their interpretation is challenging. Dried blood spots from 30,815 participants aged 6 months to 15 years from the 2018 Nigeria HIV/AIDS Indicator and Impact Survey were analyzed by multiplex bead-based assay to measure immunoglobulin G (IgG) to Pf-stage-specific MSP-1, AMA-1, GLURPR0, LSA-1, and CSP. These IgG levels were analyzed by principal component analysis (PCA).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!