Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non-osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are amenable to modification. A large number of membranes have been introduced for experimental and clinical verification. This prompts the need for an update on membrane properties and the biological outcomes, as well as a critical assessment of the biological mechanisms governing bone regeneration in defects covered by membranes. The relevant literature for this narrative review was assessed after a MEDLINE/PubMed database search. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation. Novel experimental findings also suggest an active role of the membrane compartment per se in promoting the regenerative processes in the underlying defect during GBR, instead of being purely a passive barrier. The optimization of membrane materials by systematically addressing both the barrier and the bioactive properties is an important strategy in this field of research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601292 | PMC |
| http://dx.doi.org/10.1111/eos.12364 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Co-culturing neural and bone mesenchymal stem cells in photosensitive hydrogel enhances spinal cord injury repair.
Front Bioeng Biotechnol
December 2024
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.
In mammalian species, neural tissues cannot regenerate following severe spinal cord injury (SCI), for which stem cell transplantation is a promising treatment. Neural stem cells (NSCs) have the potential to repair SCI; however, in unfavourable microenvironments, transplanted NSCs mainly differentiate into astrocytes rather than neurons. In contrast, bone mesenchymal stem cells (BMSCs) promote the differentiation of NSCs into neurons and regulate inflammatory responses.
View Article and Find Full Text PDFAmeliorative effect of venom against arthritic influence of Freund's complete adjuvant FCA in paw and ankle of male rats.
Open Vet J
November 2024
Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
Background: Pain and inflammation are closely associated with rheumatoid arthritis (RA), which affects the bones and joints.
Aim: While there are a number of therapeutic options for arthritis, their side effects restrict their use and encourage the search for alternative, natural remedies.
Methods: In male rats, we examined the anti-inflammatory and anti-arthritic properties of venom (NHV).
THE EFFECTIVENESS OF PLATELET RICH FIBRIN IN ALVEOLAR RIDGE RECONSTRUCTIVE OR GUIDED BONE REGENERATIVE PROCEDURES: A SYSTEMATIC REVIEW AND META-ANALYSIS.: platelet rich fibrin in alveolar ridge augmentation.
J Dent
December 2024
Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom. Electronic address:
Introduction And Objectives: Clinical studies have shown favorable outcomes following use of platelet rich fibrin (PRF), either alone or in conjunction with biomaterials for alveolar ridge reconstruction (ARR) or guided bone regeneration (GBR) . While PRF application accelerates wound healing and reduces postoperative discomfort, its effects on the alveolar bone gain, as part of ARR or GBR is less clear. Therefore, this study aims to investigate the clinical effectiveness of PRF when used in ARR or GBR, as well as postoperative discomfort following these procedures.
View Article and Find Full Text PDFBiological effects, properties and tissue engineering applications of polyhydroxyalkanoates: A review.
Int J Biol Macromol
December 2024
Department of Cosmetic and Plastic Surgery, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:
Polyhydroxyalkanoates (PHAs) are a group of polymers with a variety of monomers, which are extracted from microorganisms and plants. Due to its good biocompatibility, biodegradability, tunable mechanical property and piezoelectricity, PHAs have been widely used in biomedical fields, such as bone, cartilage, nerve, vascular and skin tissue engineering. This review focuses on the in vivo synthesis, metabolism and biological functions of PHA, and the applications of PHAs in the field of tissue engineering and commercial were also summarized and discussed.
View Article and Find Full Text PDFSingle-Stage Reconstruction of Large Scalp Surgical Defects With Exposed Bone Using Matriderm Flex and Full-Thickness Skin Grafts, a Case Report.
Australas J Dermatol
December 2024
Department of Dermatology, Miguel Servet University Hospital, Zaragoza, Spain.
The reconstruction of full-thickness scalp defects with exposed bone can be challenging. A single-stage reconstruction could be the preferred option for patients with multiple comorbidities. We propose using a dermal regeneration template (Matriderm Flex) and full-thickness skin grafts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!