We have developed a new set of lyophilized kits, composed of 3 different kits, for the instant preparation of no-carrier-added I-MIBG in the clinic. We here discussed the formulation of the kits, optimization of radiolabelling, quality control of radiolabeled I-MIBG, and studies of animal biodistribution. The no-carrier-added (nca) I-MIBG injection could be prepared within 30 minutes in the clinic with the help of the lyophilized kits. The radiochemical purity and specific activity (SA) could achieve above 98% and 6700 MBq/mg, respectively.
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