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[Platypnea-orthodeoxia syndrome in a patient with heart failure: A case report].

Rev Med Interne

December 2024

Service de pathologies cardiovasculaires, hôpital d'instruction des armées Laveran, 34, boulevard Laveran, CS 50004, 13384 Marseille, France.

Introduction: The platypnea orthodeoxia syndrome is a rare clinical entity combining positional dyspnea and arterial oxygen desaturation during the transition to orthostatism, reversible on return to decubitus. The most frequent etiology of this syndrome is the presence of a patent foramen ovale (PFO) responsible for a right-to-left intracardiac shunt, the severity of which results in significant functional disability and a risk of death from hypoxia.

Case Report: We report the case of a 93-year old patient on long-term oxygen, initially hospitalized for acute heart failure following a community-acquired urinary tract infection.

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Platypnea-orthodeoxia syndrome (POS) is characterized by dyspnea due to a marked fall in blood oxygen saturation while assuming standing or sitting positions. It is a rare condition with an unknown prevalence. The triggering role may remain unclear in a considerable number of patients.

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Article Synopsis
  • Platypnea orthodeoxia syndrome (POS) is a rare cause of low oxygen levels that requires careful clinical evaluation and collaboration among specialists for diagnosis.
  • An 86-year-old male presented to the ER with low oxygen saturation (84%) and did not improve with supplemental oxygen; however, his oxygen levels increased significantly when lying down.
  • Diagnosis was confirmed through echocardiography revealing a large patent foramen ovale (PFO) causing a right-to-left shunt; he was treated successfully, improving his oxygen levels and allowing him to go home without supplemental oxygen.*
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Platypnea-orthodeoxia syndrome (POS) is a rare clinical entity characterized by the onset of dyspnea and hypoxemia that normally manifests in the upright position, improving with recumbency. POS is generally caused by both anatomical and functional defects that lead to a right-to-left shunt. Herein, we present an illustrative case of POS in an elderly patient admitted for severe hypoxemia, in which a massive right-to-left shunt through a patent foramen ovale facilitated by an anatomic disturbance was found.

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Article Synopsis
  • Platypnea-orthodeoxia syndrome (POS) is a rare condition where a person experiences breathlessness and low oxygen levels when standing, but feels better when sitting or lying down, contrasting with orthopnea which worsens when lying flat.
  • A case study highlighted a 79-year-old woman with various health issues, including chronic kidney disease and a history of pulmonary embolism, who was found to have a severe patent foramen ovale (PFO) that likely contributed to her POS symptoms.
  • After successfully closing the PFO with a medical device, the patient showed significant improvement and was discharged within two days, emphasizing the importance of recognizing and treating POS to prevent serious health risks.
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