Catalytic oxidative cross-dehydrogenative coupling between unactivated C(sp)-H and C(sp)-H bonds is achieved by the cobalt-catalyzed o-alkylation reaction of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine (PIP-NH) as a N,N-bidentate directing group. Many different C(sp)-H bonds in alkanes, toluene derivatives and even in the α-position of ethers and thioethers can be used as coupling partners. This method has a broad substrate scope and the tolerance of various functional groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.7b02316 | DOI Listing |
Publication Analysis
Top Keywords
csp-h bonds
12
cross-dehydrogenative coupling
8
unactivated csp-h
8
csp-h csp-h
8
csp-h
5
cobalt-catalyzed cross-dehydrogenative
4
coupling reaction
4
reaction unactivated
4
bonds catalytic
4
catalytic oxidative
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!