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Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques. | LitMetric
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Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques.

Jin-Wu Yan Jia-Ying Zhu Kai-Xiang Zhou Jin-Sheng Wang Hui-Ya Tan Zhong-Yong Xu Shuo-Bin Chen Yu-Ting Lu Meng-Chao Cui Lei Zhang

Chem Commun (Camb)

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.

Published: August 2017

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.

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http://dx.doi.org/10.1039/c7cc05056aDOI Listing

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