Background: Linn. is considered as an established source of , whereas (Lam.) Hook. F. & Thomas is used as a source plant of in the southern part of India. In classical texts, two different varieties of , i.e. () and (), are mentioned which possess almost similar properties.
Objective: To compare antipyretic and analgesic activities of and in suitable experimental model.
Materials And Methods: Powder (540 mg/kg) and ethanolic extract (200 mg/kg) of both the test drugs ( and ) were evaluated for antipyretic activity in Brewer's yeast-induced pyrexia model in rats. Analgesic activity was evaluated by radiant heat model in rats and acetic acid-induced writhing syndrome in mice.
Results And Discussion: Result of the present study had shown that powder of (540 mg/kg) has moderate antipyretic activity as compared to the powder of and extract of both test drugs. powder showed better analgesic effect than ethanolic extract (200 mg/kg) of both the test drugs in radiant heat model in rats, while in acetic acid-induced writhing syndrome, ethanolic extract (280 mg/kg) of both drugs showed pronounced effect as compared to powder form (780 mg/kg) in mice.
Conclusion: Both and exhibited analgesic effects in experimental animals. The effect is more significant in treated group compared to . Antipyretic effect was observed with the pretreatment of .
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| http://dx.doi.org/10.4103/ayu.AYU_208_14 | DOI Listing |
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