AI Article Synopsis
- The somatopleure, a crucial part of early amniote development, has unclear boundaries and roles in forming the embryonic body.
- Researchers observed specific cell movements suggesting two main pathways leading to the formation of the amniotic and thoracic structures.
- A group of mesodermal cells from the somatopleure migrate into the embryo and are guided by signals like FGF and BMP to develop into important cardiovascular cells, highlighting the somatopleure's dual role in both amniotic structure and heart development.
Article Abstract
The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during the demarcation between intra- and extra-embryonic tissues. Here we identify cellular alignments, which indicate two streams towards the sites of dorsal amniotic closure and ventral thoracic wall formation. A subpopulation of mesodermal cells moving ventrally from the somatopleural region adjacent to the base of the head fold enter the body of the embryo and distribute to the thoracic wall, pharyngeal arches and heart. These cells are induced to differentiate into vascular endothelial cells and cardiomyocytes possibly by FGF and BMP signaling, respectively. These results indicate that the somatopleure acting as the amniotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566219 | PMC |
| http://dx.doi.org/10.1038/s41598-017-08305-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice.
iScience
February 2024
Department of Life Technologies, University of Turku, 20014 Turku, Finland.
Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during early mouse embryogenesis and that embigin is essential for lung development. Markedly increased neonatal mortality of Emb mice can be explained by the compromised lung maturation: in Emb mice (E17.
View Article and Find Full Text PDFDiverse contribution of amniogenic somatopleural cells to cardiovascular development: With special reference to thyroid vasculature.
Dev Dyn
January 2024
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Background: The somatopleure serves as the primordium of the amnion, an extraembryonic membrane surrounding the embryo. Recently, we have reported that amniogenic somatopleural cells (ASCs) not only form the amnion but also migrate into the embryo and differentiate into cardiomyocytes and vascular endothelial cells. However, detailed differentiation processes and final distributions of these intra-embryonic ASCs (hereafter referred to as iASCs) remain largely unknown.
View Article and Find Full Text PDFFoetal development of endocrine organs in dog.
Reprod Domest Anim
July 2020
Animal Health Centre, Budafok, Budapest, Hungary.
The canine adenohypophysis starts to be identifiable from 25 day of pregnancy. ACTH-immunoreactive cells migrate until day 38 after which the number of ACTH-producing cells increases but their distribution does not change. The STH- and LH-producing cells first appear on day 38 of pregnancy.
View Article and Find Full Text PDFAmniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system.
Sci Rep
August 2017
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Article Synopsis
- The somatopleure, a crucial part of early amniote development, has unclear boundaries and roles in forming the embryonic body.
- Researchers observed specific cell movements suggesting two main pathways leading to the formation of the amniotic and thoracic structures.
- A group of mesodermal cells from the somatopleure migrate into the embryo and are guided by signals like FGF and BMP to develop into important cardiovascular cells, highlighting the somatopleure's dual role in both amniotic structure and heart development.
Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregaria.
Evol Dev
March 2001
University Museum of Zoology, Department of Zoology, Cambridge, UK.
In insects, a key step in the early patterning of the egg is to distinguish the primordium of the embryo proper from those regions that will form extra-embryonic membranes. In Drosophila, where these processes are well understood, the structure of the extra-embryonic membranes is highly derived. The distinct amnion and serosa typical of lower insects is replaced by a single, fused, and much reduced membrane, the amnioserosa, which never secretes an embryonic cuticle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!