AI Article Synopsis
- We used electron cryo-tomography to visualize how cytosolic ribosomes interact with mitochondria.
- Our findings confirm that translation-arrested ribosomes are clustered around the TOM complex, linking localized translation to this organization.
- Ribosomes bind to the mitochondrial membrane in specific clusters, particularly near crista junctions, suggesting a connection between protein synthesis and transport.
Article Abstract
We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nascent chain binding is crucial for ribosome recruitment and stabilization. Ribosomes are bound to the membrane in discrete clusters, often in the vicinity of the crista junctions. This interaction highlights how protein synthesis may be coupled with transport. Our work provides unique insights into the spatial organization of cytosolic ribosomes on mitochondria.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623831 | PMC |
| http://dx.doi.org/10.15252/embr.201744261 | DOI Listing |
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